Ho roala filimi ke ts'ebetso ea bohlokoa tlhahisong ea meriana, eo ho eona ho kenngoeng karolo e tšesaane ea polymer holim'a matlapa kapa li-capsules.Ho roala hona ho sebeletsa merero e fapaneng, ho kenyelletsa ho ntlafatsa ponahalo, masking a tatso, ho sireletsa motsoako o sebetsang oa meriana (API), ho laola tokollo, le ho nolofatsa ho koenya.Hydroxypropyl Methylcellulose (HPMC) ke e 'ngoe ea li-polymer tse sebelisoang ka ho fetesisa ho koahela filimi ka lebaka la thepa ea eona e fapaneng.
1.Properties of HPMC:
Hydroxypropyl Methylcellulose (HPMC) ke semi-synthetic polymer e nkiloeng ho selulose.E khetholloa ka ho qhibiliha ha eona ha metsi, bokhoni ba ho etsa filimi, le ho lumellana hantle le metsoako e fapaneng ea meriana.Thepa ea HPMC e ka hlophisoa ka ho fetola litekanyo tse kang boima ba limolek'hule, tekanyo ea ho fetola, le viscosity.
Bokhoni ba ho Etsa Lifilimi: HPMC e na le thepa e ntle haholo ea ho etsa lifilimi, e nolofalletsang ho etsoa ha seaparo se ts'oanang le se boreleli holim'a mefuta ea litekanyetso tsa meriana.
Solubility ea Metsi: HPMC e bonts'a ho qhibiliha ha metsi, ho lumella ho qhibiliha ha polymer ka tharollo ea metsi nakong ea ho roala.Thepa ena e tiisa kabo e tšoanang ea polymer mme e thusa ho theha lera la ho roala homogeneous.
Ho khomarela: HPMC e bonts'a ho khomarela hantle holim'a matlapa kapa li-capsules, ho fella ka liphahlo tse tšoarellang tse khomarelang hantle substrate.
Thepa ea Barriers: HPMC e fana ka tšitiso khahlano le maemo a tikoloho joalo ka mongobo, oksijene le leseli, ka hona e sireletsa botšepehi ba foromo ea litekanyetso le ho matlafatsa botsitso.
2. Litlhahiso tsa Tlhahiso:
Ha ho etsoa tharollo ea ho roala filimi ka HPMC, lintlha tse 'maloa li hloka ho nahanoa ho fihlela litšobotsi tse lakatsehang tsa ho roala le ts'ebetso.
Polymer Concentration: Boiketlo ba HPMC ka tharollo ea ho roala bo susumetsa botenya le thepa ea mochini ea filimi.Likhakanyo tse phahameng tsa polymer li etsa hore ho be le meqathatso e teteaneng e nang le thepa e ntlafalitsoeng ea lithibelo.
Li-plasticizers: Ho eketsoa ha li-plasticizers tse kang polyethylene glycol (PEG) kapa propylene glycol (PG) ho ka ntlafatsa ho feto-fetoha ha maemo le elasticity ea ho roala, ho etsa hore e se ke ea brittle le ho thibela ho phunyeha.
Li-solvents: Ho bohlokoa ho khetha li-solvents tse loketseng ho netefatsa ho qhibiliha ha HPMC le sebopeho se nepahetseng sa lifilimi.Li-solvents tse tloaelehileng li kenyelletsa metsi, ethanol, isopropanol, le metsoako ea eona.
Pigments and Opacifiers: Ho kenyeletsoa ha li-pigment le opacifier ka har'a mokhoa oa ho roala ho ka fana ka 'mala, ho ntlafatsa ponahalo, le ho fana ka tšireletso e bobebe ho lithethefatsi tse bobebe.
3. Likopo tsa HPMC ho Coating Film:
Liaparo tse thehiloeng ho HPMC li fumana lits'ebetso tse ngata indastering ea meriana le ea phepo e nepahetseng ka lebaka la ho feto-fetoha ha tsona le ho tšoaneleha bakeng sa mefuta e fapaneng ea litekanyetso.
Liaparo tsa ho lokolloa hang-hang: Liaparo tsa HPMC li ka sebelisoa ho fana ka tokollo ea hang-hang ea lithethefatsi ka ho laola litekanyetso tsa ho qhalana le ho qhibiliha ha matlapa kapa li-capsules.
Liaparo tse Fetotsoeng tsa Phatlalatso: Metsoako e thehiloeng ho HPMC hangata e sebelisoa mefuteng e fetotsoeng ea litekanyetso tsa tokollo, ho kenyeletsoa tokollo e atolositsoeng le e koahetsoeng ke enteric.Ka ho fetola viscosity le botenya ba ho roala, boemo ba ho lokolloa ha lithethefatsi bo ka etsoa ho finyella tokollo e tsitsitseng kapa e lebisitsoeng.
Latsoang Masking: Liaparo tsa HPMC li ka pata tatso e sa thabiseng ea lithethefatsi, tsa ntlafatsa ho latela melao ea mokuli le ho amoheloa ha mefuta ea litekanyetso tsa molomo.
Tšireletso ea Mongobo: Liaparo tsa HPMC li fana ka tšireletso e sebetsang ea mongobo, haholo-holo bakeng sa lithethefatsi tsa hygroscopic tse atisang ho senyeha ha li pepesehela mongobo.
Ntlafatso ea Botsitso: Liaparo tsa HPMC li fana ka thibelo e sireletsang khahlanong le maemo a tikoloho, ka hona ho matlafatsa botsitso le sethala sa bophelo ba lihlahisoa tsa meriana.
Hydroxypropyl Methylcellulose (HPMC) e bapala karolo ea bohlokoa lits'ebetsong tsa ho roala lifilimi indastering ea meriana.Thepa ea eona e ikhethang, ho kenyelletsa le bokhoni ba ho etsa lifilimi, ho qhibiliha ha metsi, ho khomarela le thepa ea thibelo, e etsa hore e be khetho e nepahetseng bakeng sa ho etsa liphahlo tse nang le mesebetsi e fapaneng.Ka ho utloisisa lintlha tsa tlhahiso le lits'ebetso tsa HPMC ka ho roala filimi, baetsi ba meriana ba ka hlahisa mefuta ea litekanyetso ka ts'ebetso e ntlafetseng, botsitso le kamohelo ea mokuli.
Nako ea poso: Mar-07-2024