Hydroxypropyl methylcellulose (HPMC) ke polymer e sebelisoang hangata ho tsa meriana, litlolo, lihlahisoa tsa lijo, le lits'ebetso tse ling tse fapaneng tsa indasteri.E sebelisoa haholo ka lebaka la biocompatibility, ho se chefo, le bokhoni ba ho fetola thepa ea rheological ea tharollo.Leha ho le joalo, ho bohlokoa ho utloisisa mokhoa oa ho qhaqha HPMC ka katleho ho sebelisa thepa ea eona hantle.
Metsi: HPMC e qhibiliha haholo ka metsing, e leng se etsang hore e be khetho e ratoang bakeng sa lits'ebetso tse ngata.Leha ho le joalo, sekhahla sa ho qhibiliha se ka fapana ho latela lintlha tse kang mocheso, pH, le kereiti ea HPMC e sebelisitsoeng.
Organic Solvents: Litlhapi tse fapaneng tsa organic li ka qhala HPMC ho isa maemong a fapaneng.Tse ling tsa li-solvents tse tloaelehileng li kenyelletsa:
Joala: Isopropanol (IPA), ethanol, methanol, joalo-joalo Li-alcohols tsena li atisa ho sebelisoa ha ho etsoa meriana 'me li ka qhala HPMC ka katleho.
Acetone: Acetone ke solvent e matla e ka qhalang HPMC hantle.
Ethyl Acetate: Ke motsoako o mong oa tlhaho o ka qhalang HPMC ka katleho.
Chloroform: Chloroform ke solvent e mabifi ho feta 'me e lokela ho sebelisoa ka hloko ka lebaka la chefo ea eona.
Dimethyl Sulfoxide (DMSO): DMSO ke polar aprotic solvent e ka qhaqhang mefuta e mengata ea metsoako, ho akarelletsa le HPMC.
Propylene Glycol (PG): PG e atisa ho sebelisoa e le motsoako oa motsoako oa metsoako ea meriana.E ka qhala HPMC ka katleho 'me hangata e sebelisoa hammoho le metsi kapa metsoako e meng.
Glycerin: Glycerin, eo hape e tsejoang e le glycerol, ke motsoako o tloaelehileng oa meriana le litlolo.Hangata e sebelisoa hammoho le metsi ho qhala HPMC.
Polyethylene Glycol (PEG): PEG ke polima e nang le mokelikeli o babatsehang ka metsing le lihlapolli tse ngata tsa tlhaho.E ka sebelisoa ho qhala HPMC 'me hangata e sebelisoa mefuteng e tsoelang pele ea tokollo.
Li-surfactants: Li-surfactants tse ling li ka thusa ho qhibiliha ha HPMC ka ho fokotsa tsitsipano ea holim'a metsi le ho ntlafatsa ho kolobisa.Mehlala e kenyelletsa Tween 80, sodium lauryl sulfate (SLS), le polysorbate 80.
Li-Acti Tse Matla kapa Metheo: Le hoja e sa sebelisoe hangata ka lebaka la ts'ireletso le tšenyo e ka bang teng ea HPMC, li-acid tse matla (mohlala, hydrochloric acid) kapa li-bases (mohlala, sodium hydroxide) li ka qhala HPMC tlas'a maemo a loketseng.Leha ho le joalo, maemo a feteletseng a pH a ka lebisa ho senyeha ha polymer.
Lisebelisoa tse Ratang: Lisebelisoa tse ling tse rarahaneng joalo ka cyclodextrins li ka theha li-complexes tse kenyellelitsoeng le HPMC, tse thusang ho qhibiliha ha eona le ho ntlafatsa ho qhibiliha ha eona.
Mocheso: Ka kakaretso, lithempereichara tse phahameng li eketsa sekhahla sa ho qhibiliha ha HPMC ka lihlapolli tse kang metsi.Leha ho le joalo, mocheso o phahameng haholo o ka theola polymer, kahoo ho bohlokoa ho sebetsa ka har'a mefuta e sireletsehileng ea mocheso.
Mechanical Agitation: Ho hlohlelletsa kapa ho kopanya ho ka thusa ho qhibiliha ha HPMC ka ho eketsa kamano pakeng tsa polymer le solvent.
Boholo ba Particle: HPMC e nang le phofshoana e ntle e tla qhibiliha habonolo ho feta likaroloana tse kholoanyane ka lebaka la ho eketseha ha sebaka sa holimo.
Ke habohlokoa ho hlokomela hore khetho ea maemo a solvent le ho qhibiliha e itšetlehile ka tšebeliso e khethehileng le thepa e lakatsehang ea sehlahisoa sa ho qetela.Ho lumellana le lisebelisoa tse ling, lintlha tsa polokeho, le litlhoko tsa taolo le tsona li susumetsa khetho ea lihlapolli le mekhoa ea ho qhala.Ho feta moo, ho bohlokoa ho etsa lithuto tsa tšebelisano le liteko tsa botsitso ho netefatsa hore ts'ebetso ea ho qhala ha e ame boleng kapa ts'ebetso ea sehlahisoa sa ho qetela.
Nako ea poso: Mar-22-2024