Hydroxypropylmethylcellulose (HPMC) ke motsoako o feto-fetohang le o feto-fetohang oa lelapa la cellulose ether.E tsoa ho cellulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela.HPMC e sebelisoa haholo liindastering tse fapaneng ho kenyelletsa le tsa meriana, lijo, kaho le litlolo ka lebaka la thepa ea eona e ikhethang le melemo e mengata.
1. Indasteri ea meriana:
A. Tokisetso e tsitsitseng ea tokollo:
HPMC e sebelisoa haholo indastering ea meriana ka lebaka la bokhoni ba eona ba ho etsa matrix ea gel ha e le metsi.Thepa ena e bohlokoa haholo ho nts'etsopele ea litlhare tse sa khaotseng.Ka ho laola sekhahla sa viscosity le gelation ea HPMC, bahlahisi ba meriana ba ka fihlela lintlha tse atolositsoeng tsa tokollo ea lithethefatsi, ba ntlafatsa ho latela melao ea mokuli le ho fokotsa khafetsa ea dosing.
b.Ho roala filimi e nyane:
HPMC e atisa ho sebelisoa e le moemeli oa ho roala filimi bakeng sa matlapa.E fana ka seaparo se boreleli, se ts'oanang se ntlafatsang ponahalo ea matlapa, se pata tatso ea lithethefatsi, 'me se sireletsa linthong tsa tikoloho.Thepa ea ho etsa lifilimi ea HPMC e thusa ho ntlafatsa botsitso ba lithethefatsi le bioavailability.
C. Phano e Laolang ea Lithethefatsi:
The biocompatibility and inert nature of HPMC e etsa hore e loketse ho sebelisoa litsamaisong tse laoloang tsa phano ea lithethefatsi.E ka sebelisoa hammoho le li-polymers tse ling ho fetola kinetics ea ho lokolloa ha lithethefatsi, ho lumella taolo e nepahetseng ea litekanyetso tsa ho fana ka lithethefatsi le ho fokotsa kotsi ea litla-morao.
d.Setlamo sa Letlapa:
HPMC e sebetsa joalo ka setlamo se sebetsang sa letlapa, se thusang ho fana ka mokhoa oa ho khomarela liforomo tsa letlapa.E etsa bonnete ba ho kopana ho nepahetseng ha metsoako, ho fella ka ho thatafala ho tšoanang le botšepehi ba matlapa.
2. Indasteri ea lijo:
A. Thickeners le li-gellling agents:
Indastering ea lijo, HPMC e sebelisoa e le ntho e teteaneng le ea gelling.E fa lijo mokhoa o lakatsehang le ho ntlafatsa boleng ba eona ka kakaretso.HPMC e atisa ho sebelisoa lihlahisoa tse kang li-sauces, sopho le lijo tse theolelang ho finyella botsitso bo lakatsehang.
b.Ho fetola mafura:
HPMC e ka sebelisoa e le sebaka sa mafura lijong tse itseng, ho thusa ho hlahisa mefuta e meng ea mafura a tlase kapa a se nang mafura.Sena ke sa bohlokoa ka ho khetheha molemong oa ho sebetsana le litaba tsa bophelo bo botle tse amanang le tšebeliso e feteletseng ea mafura.
C. emulsification:
Ka lebaka la thepa ea eona ea emulsifying, HPMC e sebelisoa ho hlahisa lijo tse emulsified.E thusa ho tsitsisa li-emulsions, ho thibela karohano ea mekhahlelo le ho netefatsa sehlahisoa sa homogeneous.
d.Moemeli oa ho bentša:
HPMC e sebelisoa e le sesebelisoa se benyang indastering ea lijo ho fana ka seaparo se benyang le se khahlang ho lipompong, litholoana le lihlahisoa tse ling tsa lijo.
3. Indasteri ea kaho:
A. Sekhomaretsi sa lithaele:
HPMC ke motsoako o ka sehloohong oa sekhomaretsi sa lithaele mme e sebetsa joalo ka sekontiri le se bolokang metsi.E matlafatsa ts'ebetso ea seretse se tlamang, ho etsa hore kaho e be bonolo le ho ntlafatsa matla a tlamo.
b.Seretse sa samente:
Lirapeng tse thehiloeng ho samente, HPMC e sebelisetsoa ho ntlafatsa ho boloka metsi, ho sebetsa le ho khomarela.E thusa ho ntlafatsa thepa ea kakaretso ea seretse, ho etsa hore ho be bonolo ho sebetsana le ho netefatsa ho khomarela hantle holimo.
C. Metsoako ea ho ikemela:
HPMC e kenyelelitsoe ho li-self-leveling metsoako ho laola viscosity le ho ntlafatsa litšobotsi tsa phallo.Sena ke sa bohlokoa ho fumana sebaka se boreleli, se leka-lekaneng ha u sebelisa fatše.
d.Gypsum le stucco:
Ho eketsa HPMC ho gypsum le stucco formulations ho ntlafatsa ho khomarela, ho sebetsa le ho boloka metsi.E thusa ho ntlafatsa boleng ba kakaretso ea sebaka se phethiloeng, ho fokotsa monyetla oa ho phatloha le ho eketsa nako e telele.
4. Indasteri ea litlolo:
A. Thickeners ka litlolo le litlolo:
HPMC e atisa ho sebelisoa e le setsi se teteaneng ka mekhoa ea litlolo tse kang litlolo le litlolo.E etsa hore sehlahisoa se be le sebopeho se boreleli, se monate, 'me se matlafatsa kutlo ea sona.
b.Lisebelisoa tse etsang lifilimi lihlahisoa tsa tlhokomelo ea moriri:
Ka lihlahisoa tsa tlhokomelo ea moriri tse kang li-gels tsa moriri le litlolo tsa setaele, HPMC e sebetsa joalo ka moemeli oa ho etsa lifilimi.E thusa ho theha filimi e tenyetsehang, e tšoarellang ka moriri, e thusa ho ntlafatsa ho tšoara le ho laola.
C. Emulsion stabilizer:
Thepa e tsitsitseng ea HPMC e etsa hore e be ea bohlokoa ho emulsion formulations ho thibela karohano ea mekhahlelo le ho netefatsa botsitso ba sehlahisoa ka nako.
d.Phatlalatso e laoloang ka libopeho tsa lihlooho:
Joalo ka ts'ebeliso ea eona litlhare, HPMC e ka sebelisoa ho litlolo tsa litlolo ho fihlela tokollo e laoloang ea metsoako e sebetsang.Sena ke sa bohlokoa ka ho khetheha bakeng sa lihlahisoa tsa tlhokomelo ea letlalo tse hlokang tokollo e tsitsitseng ea metsoako e molemo.
5. Melemo e meng:
A. Ho boloka metsi:
HPMC e na le thepa e ntle ea ho boloka metsi, e etsa hore e be ea bohlokoa lits'ebetsong tse fapaneng moo ho boloka maemo a mongobo ho leng bohlokoa.Sena se na le molemo ka ho khetheha mekhoeng e itseng ea indasteri ea kaho le indastering ea lijo le ea litlolo.
b.Biodegradability:
HPMC ke polymer e ka bolang e tsamaellanang le khatello e ntseng e hola ea lisebelisoa tse baballang tikoloho le tse tšoarellang.Thepa ea eona e ka senyehang e fokotsa tšusumetso ea tikoloho, e etsa hore e be khetho ea pele bakeng sa lits'ebetso tse itseng.
C. Ho lumellana le li-polymers tse ling:
HPMC e na le tumellano e ntle le mefuta e meng ea li-polymers, e lumellang litsamaiso tse rarahaneng ho etsoa ho latela litlhoko tse khethehileng tsa kopo.
d.Ha e na chefo le inert:
HPMC e nkuoa e se chefo ebile e se na chefo, e etsa hore e bolokehe bakeng sa tšebeliso ea meriana, lijo, litlolo le lits'ebetso tse ling moo polokeho ea bareki e leng bohlokoa.
Hydroxypropyl methylcellulose (HPMC) e hlahella liindasteri tse fapaneng e le motsoako o sebetsang ka bongata le o molemo.E thusa ho theha litsamaiso tse lokolotsoeng tse laoloang, ho ntlafatsa ts'ebetso ea lijo le litlolo, le ho ntlafatsa thepa ea thepa ea kaho, e totobatsang ho feto-fetoha ha eona le bohlokoa ba mekhoa ea sejoale-joale ea tlhahiso.Ha indasteri e ntse e tsoela pele ho fetoha, HPMC e kanna ea lula e le motsoako oa bohlokoa ho nts'etsopele ea lihlahisoa tse ncha le tsa boleng bo holimo.
Nako ea poso: Dec-18-2023