Hydroxypropylmethylcellulose (HPMC), e le hydrophilic polymer e sebelisoang ka tloaelo indastering ea meriana, e sebelisoa haholo ka ho roala letlapa, mekhoa e laoloang ea tokollo le mekhoa e meng ea phepelo ea lithethefatsi.E 'ngoe ea litšobotsi tsa bohlokoa tsa HPMC ke bokhoni ba eona ba ho boloka metsi, e amang ts'ebetso ea eona joalo ka mothusi oa meriana.Sehloohong sena, re tla hlahloba lintlha tsa bohlokoa tse amang ho bolokoa ha metsi ha HPMC, ho kenyeletsoa boima ba limolek'hule, mofuta oa sebaka, mahloriso le pH.
boima ba molek'hule
Boima ba limolek'hule tsa HPMC bo bapala karolo ea bohlokoa ho lekanyeng matla a eona a ho boloka metsi.Ka kakaretso, boima bo phahameng ba limolek'hule HPMC e na le hydrophilic ho feta boima bo tlaase ba molek'hule HPMC 'me e ka monya metsi a mangata.Sena ke hobane limolek'hule tse phahameng tsa HPMCs li na le liketane tse telele tse ka kopanyang le ho theha marang-rang a mangata, ho eketsa bongata ba metsi a ka kenngoa.Leha ho le joalo, ho lokela ho hlokomeloa hore boima bo bongata ba limolek'hule HPMC bo tla baka mathata a kang viscosity le mathata a ho sebetsa.
mofuta o mong
Ntho e 'ngoe e amang matla a ho boloka metsi a HPMC ke mofuta oa ho fetola.HPMC ka kakaretso e tla ka mefuta e 'meli: hydroxypropyl-substituted le methoxy-substituted.Mofuta o nkeloang sebaka ke hydroxypropyl o na le matla a holimo a ho monya metsi ho feta mofuta o nkeloang sebaka ke methoxy.Sena ke hobane sehlopha sa hydroxypropyl se teng ka har'a molek'hule ea HPMC ke hydrophilic mme se eketsa kamano ea HPMC bakeng sa metsi.Ka lehlakoreng le leng, mofuta oa methoxy-substituted ha o na hydrophilic e nyane mme ka hona o na le matla a tlase a ho boloka metsi.Ka hona, mefuta e meng ea HPMC e lokela ho khethoa ka hloko ho latela thepa e lakatsehang ea sehlahisoa sa ho qetela.
tsepamisa maikutlo ho
Khatiso ea HPMC e boetse e ama matla a eona a ho boloka metsi.Maemong a tlase, HPMC ha e thehe sebopeho se kang gel, kahoo matla a eona a ho boloka metsi a tlase.Ha mahloriso a HPMC a ntse a eketseha, limolek'hule tsa polymer li ile tsa qala ho ts'oarana, tsa etsa sebopeho se kang gel.Marang-rang ana a gel a monya le ho boloka metsi, 'me matla a ho boloka metsi a HPMC a eketseha ka mahloriso.Leha ho le joalo, ho lokela ho hlokomeloa hore khatello e phahameng haholo ea HPMC e tla lebisa mathateng a ho qapa joalo ka viscosity le mathata a ho sebetsa.Ka hona, khatello ea HPMC e sebelisitsoeng e lokela ho ntlafatsoa ho fihlela bokhoni bo lakatsehang ba ho boloka metsi ha ho ntse ho qoba mathata a boletsoeng ka holimo.
PH boleng
Boleng ba pH ba tikoloho moo HPMC e sebelisoang le bona bo tla ama bokhoni ba eona ba ho boloka metsi.Sebopeho sa HPMC se na le lihlopha tsa anionic (-COO-) le lihlopha tsa hydrophilic ethylcellulose (-OH).The ionization ea -COO- lihlopha e itšetlehile ka pH, 'me tekanyo ea bona ea ionization e eketseha ka pH.Ka hona, HPMC e na le bokhoni bo phahameng ba ho boloka metsi ka pH e phahameng.Ka pH e tlase, sehlopha sa -COO- se na le protonated mme hydrophilicity ea eona ea fokotseha, e leng se bakang ho fokotsa matla a ho boloka metsi.Ka hona, pH ea tikoloho e lokela ho ntlafatsoa ho fihlela bokhoni bo lakatsehang ba ho boloka metsi ba HPMC.
ha re phethela
Qetellong, matla a ho boloka metsi a HPMC ke ntlha ea bohlokoa e amang ts'ebetso ea eona e le mothusi oa meriana.Lintlha tsa bohlokoa tse amang matla a ho boloka metsi a HPMC li kenyelletsa boima ba limolek'hule, mofuta oa sebaka, mahloriso le boleng ba pH.Ka ho lokisa lintlha tsena ka hloko, matla a ho boloka metsi a HPMC a ka ntlafatsoa ho fihlela thepa e lakatsehang ea sehlahisoa sa ho qetela.Bafuputsi ba meriana le bahlahisi ba lokela ho ela hloko lintlha tsena ho netefatsa boleng bo phahameng ka ho fetisisa le ts'ebetso ea litlhare tse thehiloeng ho HPMC.
Nako ea poso: Aug-05-2023