Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa meriana, litlolo, lijo le kaho.Bokhoni ba eona ba ho etsa li-gel, lifilimi le tharollo bo etsa hore e be ea bohlokoa bakeng sa lits'ebetso tse ngata.Hydration ea HPMC ke mohato oa bohlokoa lits'ebetsong tse ngata, kaha e thusa polymer ho bonts'a thepa ea eona e lakatsehang ka nepo.
1. Ho utloisisa HPMC:
HPMC e tsoa ho selulose 'me e entsoe ka ho phekola selulose ka propylene oxide le methyl chloride.E khetholloa ka ho qhibiliha ha eona ha metsi le bokhoni ba ho etsa li-gel tse hlakileng, tse fetohang ka mocheso.Tekanyo ea hydroxypropyl le methoxyl substitution e ama thepa ea eona, ho kenyelletsa le solubility, viscosity, le boitšoaro ba gelation.
2. Bohlokoa ba Hydration:
Hydration e bohlokoa ho notlolla ts'ebetso ea HPMC.Ha HPMC e na le metsi, e monya metsi le ho ruruha, e lebisang ho thehoeng ha tharollo ea viscous kapa gel, ho itšetlehile ka mahloriso le maemo.Boemo bona ba hydrated bo thusa HPMC ho etsa mesebetsi e reriloeng, joalo ka ho tenya, ho tlotsa, ho etsa filimi, le ho ts'ehetsa tokollo ea lithethefatsi.
3. Mekhoa ea ho futhumatsa metsi:
Ho na le mekhoa e 'maloa ea ho nosetsa HPMC, ho latela ts'ebeliso le sephetho se lakatsehang:
a.Phallo ea Metsi a Batang:
Mokhoa ona o kenyelletsa ho qhala phofo ea HPMC metsing a batang ha o ntse o hlohlelletsa ka bonolo.
Phallo ea metsi a batang e ratoa ho thibela ho putlama le ho netefatsa hore metsi a ts'oane.
Ka mor'a ho hasana, tharollo hangata e lumelloa ho hydrate ho ea pele tlas'a pherekano e bonolo ho finyella viscosity e lakatsehang.
b.Phallo ea Metsi a Chesang:
Ka mokhoa ona, phofo ea HPMC e hasane ka metsing a chesang, hangata ka mocheso o ka holimo ho 80 ° C.
Metsi a chesang a thusa ho phalla ka potlako le ho qhibiliha ha HPMC, ho fella ka tharollo e hlakileng.
Tlhokomelo e tlameha ho nkuoa ho qoba ho futhumala ho feteletseng, ho ka theolang HPMC kapa ho baka leqeba.
c.Ho se nke lehlakore:
Lisebelisoa tse ling li ka kenyelletsa ho fokotsa litharollo tsa HPMC ka lisebelisoa tsa alkaline joalo ka sodium hydroxide kapa potasiamo hydroxide.
Neutralization e lokisa pH ea tharollo, e ka susumetsang viscosity le gelation properties tsa HPMC.
d.Solvent Exchange:
HPMC e ka boela ea tšeloa metsi ka phapanyetsano ea solvent, moo e qhalakantsoeng ka har'a motsoako oa metsi-miscible joaloka ethanol kapa methanol ebe e fapanyetsana le metsi.
Phapanyetsano ea solvent e ka ba molemo bakeng sa lits'ebetso tse hlokang taolo e nepahetseng holim'a hydration le viscosity.
e.Pre-hydration:
Pre-hydration e kenyelletsa ho inela HPMC metsing kapa mokelikeli pele o e kenyelletsa metsoakong.
Mokhoa ona o etsa bonnete ba hore o na le metsi a mangata 'me o ka ba molemo bakeng sa ho finyella liphello tse tsitsitseng, haholo-holo ka mekhoa e rarahaneng.
4. Lintlha tse Amang ho Felisoa ha metsi:
Lintlha tse 'maloa li susumetsa hydration ea HPMC:
a.Boholo ba Particle: Phofo ea HPMC e entsoeng ka khase e nang le hydrate e bonolo ho feta likaroloana tse mahoashe ka lebaka la ho eketseha ha sebaka.
b.Thempereichara: Lithempereichara tse phahameng ka kakaretso li potlakisa hydration empa li ka boela tsa ama viscosity le boitšoaro ba gelation ba HPMC.
c.pH: The pH ea hydration medium e ka ama boemo ba ionization ba HPMC mme ka lebaka leo hydration kinetics ea eona le thepa ea rheological.
d.Ho kopanya: Ho kopanya hantle kapa ho ferekana ho bohlokoa bakeng sa ho tsamaisa metsi ka mokhoa o ts'oanang le ho hasana ha likaroloana tsa HPMC ka har'a solvent.
e.Concentration: The concentration of HPMC in the hydration medium e susumetsa viscosity, matla a gel, le litšobotsi tse ling tsa tharollo kapa gel e hlahisoang.
5. Likopo:
Hydrated HPMC e fumana lits'ebetso tse fapaneng ho liindasteri tse fapaneng:
a.Mekhabiso ea Meriana: Lirapeng tsa letlapa, li-matrices tse lokolotsoeng tse laoloang, litharollo tsa mahlo, le li-suspensions.
b.Lihlahisoa tsa Lijo: Joalo ka setei, se tsitsisa, kapa se etsa lifilimi ka lisoso, liaparo, lihlahisoa tsa lebese le li-confectionery.
c.Litlolo: Ka litlolo, litlolo, li-gel, le litlolo tse ling bakeng sa phetoho ea viscosity le emulsification.
d.Lisebelisoa tsa Kaho: Ka lihlahisoa tse thehiloeng ho samente, likhomaretsi tsa lithaele, le lisebelisoa ho ntlafatsa ts'ebetso, ho boloka metsi le ho khomarela.
6. Taolo ea Boleng:
Matla a hydration a HPMC a bohlokoa bakeng sa ts'ebetso ea sehlahisoa le botsitso.Mehato ea taolo ea boleng e ka kenyelletsa:
a.Tlhahlobo ea Boholo ba Particle: Ho netefatsa ho lekana ha kabo ea boholo ba likaroloana ho ntlafatsa kinetics ea hydration.
b.Tekanyo ea Viscosity: Ho lekola viscosity nakong ea hydration ho fihlela tumellano e lakatsehang bakeng sa ts'ebeliso e reriloeng.
c.pH Monitoring: Ho laola pH ya hydration medium ho matlafatsa metsi le ho thibela ho senyeha.
d.Tlhahlobo ea Microscopic: Tlhahlobo ea pono ea lisampole tse hydrated ka tlas'a microscope ho hlahloba ho hasana ha likaroloana le botšepehi.
7. Qetello:
Hydration ke ts'ebetso ea mantlha ea ho sebelisa thepa ea HPMC bakeng sa lits'ebetso tse fapaneng.Ho utloisisa mekhoa, lintlha, le mehato ea taolo ea boleng e amanang le hydration ho bohlokoa bakeng sa ho ntlafatsa ts'ebetso ea sehlahisoa le ho netefatsa ts'ebetso e ts'oanang ea tlhahiso.Ka ho tseba ho tsamaisa metsi hoa HPMC, bafuputsi le baetsi ba lihlahisoa ba ka notlolla matla a eona a felletseng ho liindasteri tse fapaneng, ba khanna boqapi le nts'etsopele ea lihlahisoa.
Nako ea poso: Mar-04-2024