Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa meriana, litlolo, lijo le kaho. Bokhoni ba eona ba ho etsa li-gel, lifilimi le tharollo bo etsa hore e be ea bohlokoa bakeng sa lits'ebetso tse ngata. Hydration ea HPMC ke mohato oa bohlokoa lits'ebetsong tse ngata, kaha e thusa polymer ho bonts'a thepa ea eona e lakatsehang ka nepo.
1. Ho utloisisa HPMC:
HPMC e tsoa ho selulose 'me e entsoe ka ho phekola selulose ka propylene oxide le methyl chloride. E khetholloa ka ho qhibiliha ha eona ha metsi le bokhoni ba ho etsa li-gel tse hlakileng, tse fetohang ka mocheso. Tekanyo ea hydroxypropyl le methoxyl substitution e ama thepa ea eona, ho kenyelletsa le solubility, viscosity, le boitšoaro ba gelation.
2. Bohlokoa ba Hydration:
Hydration e bohlokoa ho notlolla ts'ebetso ea HPMC. Ha HPMC e na le metsi, e monya metsi le ho ruruha, e lebisang ho thehoeng ha tharollo ea viscous kapa gel, ho itšetlehile ka mahloriso le maemo. Boemo bona ba hydrated bo thusa HPMC ho etsa mesebetsi e reriloeng, joalo ka ho tenya, ho tlotsa, ho etsa filimi, le ho ts'ehetsa tokollo ea lithethefatsi.
3. Mekhoa ea ho futhumatsa metsi:
Ho na le mekhoa e 'maloa ea ho nosetsa HPMC, ho latela ts'ebeliso le sephetho se lakatsehang:
a. Phallo ea Metsi a Batang:
Mokhoa ona o kenyelletsa ho qhala phofo ea HPMC metsing a batang ha o ntse o hlohlelletsa ka bonolo.
Phallo ea metsi a batang e ratoa ho thibela ho putlama le ho netefatsa hore metsi a ts'oane.
Ka mor'a ho hasana, tharollo hangata e lumelloa ho hydrate ho ea pele tlas'a pherekano e bonolo ho finyella viscosity e lakatsehang.
b. Phallo ea Metsi a Chesang:
Ka mokhoa ona, phofo ea HPMC e hasane ka metsing a chesang, hangata ka mocheso o ka holimo ho 80 ° C.
Metsi a chesang a thusa ho phalla ka potlako le ho qhibiliha ha HPMC, ho fella ka tharollo e hlakileng.
Tlhokomelo e tlameha ho nkuoa ho qoba ho futhumala ho feteletseng, ho ka theolang HPMC kapa ho baka leqeba.
c. Ho se nke lehlakore:
Lisebelisoa tse ling li ka kenyelletsa ho fokotsa litharollo tsa HPMC ka lisebelisoa tsa alkaline joalo ka sodium hydroxide kapa potasiamo hydroxide.
Neutralization e lokisa pH ea tharollo, e ka susumetsang viscosity le gelation properties tsa HPMC.
d. Solvent Exchange:
HPMC e ka boela ea tšeloa metsi ka phapanyetsano ea solvent, moo e qhalakantsoeng ka har'a motsoako oa metsi-miscible joaloka ethanol kapa methanol ebe e fapanyetsana le metsi.
Phapanyetsano ea solvent e ka ba molemo bakeng sa lits'ebetso tse hlokang taolo e nepahetseng holim'a hydration le viscosity.
e. Pre-hydration:
Pre-hydration e kenyelletsa ho inela HPMC metsing kapa mokelikeli pele o e kenyelletsa metsoakong.
Mokhoa ona o etsa bonnete ba hore o na le metsi a mangata 'me o ka ba molemo bakeng sa ho finyella liphello tse tsitsitseng, haholo-holo ka mekhoa e rarahaneng.
4. Lintlha tse Amang ho Felisoa ha metsi:
Lintlha tse 'maloa li susumetsa hydration ea HPMC:
a. Boholo ba Particle: Phofo ea HPMC e entsoeng ka khase e nang le hydrate e bonolo ho feta likaroloana tse mahoashe ka lebaka la ho eketseha ha sebaka.
b. Thempereichara: Lithempereichara tse phahameng ka kakaretso li potlakisa hydration empa li ka boela tsa ama viscosity le boitšoaro ba gelation ba HPMC.
c. pH: The pH ea hydration medium e ka ama boemo ba ionization ba HPMC mme ka lebaka leo hydration kinetics ea eona le thepa ea rheological.
d. Ho kopanya: Ho kopanya hantle kapa ho ferekana ho bohlokoa bakeng sa ho tsamaisa metsi ka mokhoa o ts'oanang le ho hasana ha likaroloana tsa HPMC ka har'a solvent.
e. Concentration: The concentration of HPMC in the hydration medium e susumetsa viscosity, matla a gel, le litšobotsi tse ling tsa tharollo kapa gel e hlahisoang.
5. Likopo:
Hydrated HPMC e fumana lits'ebetso tse fapaneng ho liindasteri tse fapaneng:
a. Mekhabiso ea Meriana: Lirapeng tsa letlapa, li-matrices tse lokolotsoeng tse laoloang, litharollo tsa mahlo, le li-suspensions.
b. Lihlahisoa tsa Lijo: Joalo ka setei, se tsitsisa, kapa se etsa lifilimi ka lisoso, liaparo, lihlahisoa tsa lebese le li-confectionery.
c. Litlolo: Ka litlolo, litlolo, li-gel, le litlolo tse ling bakeng sa phetoho ea viscosity le emulsification.
d. Lisebelisoa tsa Kaho: Ka lihlahisoa tse thehiloeng ho samente, likhomaretsi tsa lithaele, le lisebelisoa ho ntlafatsa ts'ebetso, ho boloka metsi le ho khomarela.
6. Taolo ea Boleng:
Matla a hydration a HPMC a bohlokoa bakeng sa ts'ebetso ea sehlahisoa le botsitso. Mehato ea taolo ea boleng e ka kenyelletsa:
a. Tlhahlobo ea Boholo ba Particle: Ho netefatsa ho lekana ha kabo ea boholo ba likaroloana ho ntlafatsa kinetics ea hydration.
b. Tekanyo ea Viscosity: Ho lekola viscosity nakong ea hydration ho fihlela tumellano e lakatsehang bakeng sa ts'ebeliso e reriloeng.
c. pH Monitoring: Ho laola pH ya hydration medium ho matlafatsa metsi le ho thibela ho senyeha.
d. Tlhahlobo ea Microscopic: Tlhahlobo ea pono ea lisampole tse hydrated ka tlas'a microscope ho hlahloba ho hasana ha likaroloana le botšepehi.
7. Qetello:
Hydration ke ts'ebetso ea mantlha ea ho sebelisa thepa ea HPMC bakeng sa lits'ebetso tse fapaneng. Ho utloisisa mekhoa, lintlha, le mehato ea taolo ea boleng e amanang le hydration ho bohlokoa bakeng sa ho ntlafatsa ts'ebetso ea sehlahisoa le ho netefatsa ts'ebetso e ts'oanang ea litlhophiso. Ka ho tseba ho tsamaisa metsi hoa HPMC, bafuputsi le baetsi ba lihlahisoa ba ka notlolla bokhoni ba eona bo felletseng ho tsoa liindastering tse fapaneng, ba tsamaisa boqapi le nts'etsopele ea lihlahisoa.
Nako ea poso: Mar-04-2024