Tšebeliso ea HPMC Lefapheng la Meriana

Hydroxypropyl methylcellulose (HPMC), eo hape e tsejoang e le hypromellose, e sebelisoa haholo indastering ea meriana ka lebaka la thepa ea eona e fapaneng. Mona ke tse ling tsa lits'ebetso tse tloaelehileng tsa HPMC litlameng tsa meriana:

1. Letlapa Binder: HPMC hangata e sebelisoa joalo ka setlamo mefuteng ea matlapa ho fana ka momahano le ho ntlafatsa ho thatafala ha letlapa. E thusa ho tšoara metsoako e phofshoana hammoho nakong ea khatello, e hlahisang matlapa a nang le ho tšoana le matla a mochine.
2. Film Coating Agent: HPMC e sebelisoa e le moemeli oa ho roala filimi ho fana ka tšireletso le / kapa seaparo se setle holim'a matlapa le li-capsules. Ho roala filimi ho ntlafatsa ponahalo, tatso ea masking, le botsitso ba foromo ea litekanyetso tsa meriana. Ho feta moo, e ka laola kinetics ea tokollo ea lithethefatsi, ea sireletsa sethethefatsi ho tloha mongobo, 'me ea nolofatsa ho metsa.
3. Matrix Former: HPMC e sebelisoa e le matrix ea pele ho liforomo tsa matlapa tse laoloang le tse lokollotsoeng ka nako e telele. E theha gel layer holim'a hydration, e laolang ho hasana ha moriana ho tloha foromong ea litekanyetso, e lebisang ho lokolloa ha lithethefatsi nako e telele le phello e tsitsitseng ea phekolo.
4. Disintegrant: Litlhahiso tse ling, HPMC e ka sebetsa e le e senyang, e khothalletsang karohano e potlakileng le ho hasana ha matlapa kapa li-capsules ka har'a pampiri ea mala. Sena se thusa ho qhala le ho monyela ha lithethefatsi, ho netefatsa bioavailability e nepahetseng.
5. Viscosity Modifier: HPMC e sebelisoa joalo ka sebopeho sa viscosity mekhoeng ea mokelikeli le e batlang e tiile joalo ka li-suspensions, li-emulsion, li-gel, le litlolo. E fana ka taolo ea rheological, e ntlafatsa botsitso ba ho fanyeha, 'me e matlafatsa ho ata le ho khomarela ha metsoako ea lihlooho.
6. Stabilizer le Emulsifier: HPMC e sebelisoa e le stabilizer le emulsifier mekhoeng ea mokelikeli ho thibela karohano ea mekhahlelo, ho ntlafatsa botsitso ba ho emisa, le ho ntlafatsa homogeneity ea sehlahisoa. Hangata e sebelisoa ha ho emisoa ka molomo, li-syrups le li-emulsions.
7. Thickening Agent: HPMC e sebelisoa e le ntho e matlafatsang mefuteng e fapaneng ea meriana ho eketsa viscosity le ho fana ka thepa e lakatsehang ea rheological. E ntlafatsa sebopeho le ho tsitsisa ha litokisetso tsa lihlooho tse kang litlolo, li-lotion le li-gel, ho matlafatsa ho ata ha tsona le ho ikutloa ha letlalo.
8. Opacifier: HPMC e ka sebelisoa e le sesebelisoa sa opacifying mefuteng e itseng ho fana ka taolo ea opacity kapa opacity. Thepa ena e na le thuso ka ho khetheha ho ophthalmic formulations, moo opacity e ka ntlafatsang ponahalo ea sehlahisoa nakong ea tsamaiso.
9. Koloi bakeng sa Mekhoa ea Phano ea Lithethefatsi: HPMC e sebelisoa e le koloi kapa sejari mekhoeng ea ho fana ka lithethefatsi tse kang microspheres, nanoparticles, le hydrogels. E ka kenyelletsa lithethefatsi, ea laola kinetics ea ho lokolloa ha lithethefatsi, le ho matlafatsa botsitso ba lithethefatsi, ho fana ka phano ea lithethefatsi e lebisitsoeng le e laoloang.

HPMC ke setsebi sa meriana se nang le mekhoa e mengata e fapaneng ea lisebelisoa, ho kenyelletsa le ho tlama letlapa, ho roala filimi, ho thehoa ha matrix a laoloang, ho arohana, phetoho ea viscosity, stabilization, emulsification, thickening, opacification, le tlhahiso ea tsamaiso ea tsamaiso ea lithethefatsi. Tšebeliso ea eona e kenya letsoho ntlafatsong ea lihlahisoa tsa meriana tse bolokehileng, tse sebetsang hantle le tse bonolo ho mokuli.