Hydroxypropylmethylcellulose (HPMC) ke motsoako oa cellulose o sebelisoang hangata liindastering tse fapaneng, ho kenyeletsoa meriana, kaho le lijo. Viscosity ea eona e ka fapana ho ea ka lintlha tse kang boima ba molek'hule, tekanyo ea ho fetola, le ho tsepamisa mohopolo oa tharollo.
Selelekela sa Hydroxypropyl Methylcellulose (HPMC)
Hydroxypropyl methylcellulose ke semi-synthetic polymer e fumanoang ka ho fetola lik'hemik'hale tsa selulose. Ka lebaka la thepa ea eona e ikhethang, e sebelisoa haholo e le motenya, moemeli oa gelling, oa pele oa filimi le stabilizer lits'ebetsong tse fapaneng.
Sebopeho le sebopeho sa limolek'hule
HPMC e na le mokokotlo oa cellulose o nang le hydroxypropyl le methoxy substituents. The degree of substitution (DS) e bolela palohare ea palo ea lintho tse nkeloang sebaka ka yuniti ea anhydroglucose ka har'a ketane ea selulose. Boleng bo ikhethileng ba DS bo ama thepa ea 'mele le ea lik'hemik'hale ea HPMC.
HPMC viscosity
Viscosity ke paramethara ea bohlokoa bakeng sa HPMC, haholo lits'ebetsong tse sebelisang thepa ea eona e teteaneng le ea gelling.
Viscosity ea tharollo ea HPMC e angoa ke lintlha tse ngata:
1. Boima ba molek'hule
Boima ba limolek'hule tsa HPMC bo ama viscosity ea eona. Ka kakaretso, limolek'hule tse phahameng tsa HPMCs li atisa ho hlahisa litharollo tse phahameng tsa viscosity. Ho na le limaraka tse fapaneng tsa HPMC 'marakeng, e' ngoe le e 'ngoe e na le mefuta ea eona ea boima ba limolek'hule.
2. Degree of substitution (DS)
Litekanyetso tsa DS tsa hydroxypropyl le lihlopha tsa methoxy li ama ho solubility le viscosity ea HPMC. Litekanyetso tse phahameng tsa DS hangata li fella ka ho eketsa ho qhibiliha ha metsi le litharollo tse teteaneng.
3. Ho tsepamisa mohopolo
Khokahano ea HPMC ka tharollo ke ntlha ea bohlokoa e amang viscosity. Ha mahloriso a ntse a eketseha, viscosity hangata ea eketseha. Kamano ena hangata e hlalosoa ke equation ea Krieger-Dougherty.
4. Mocheso
Mocheso o boetse o ama viscosity ea tharollo ea HPMC. Ka kakaretso, viscosity ea fokotseha ha mocheso o ntse o eketseha.
Libaka tsa kopo
Meriana ea Meriana: HPMC e atisa ho sebelisoa ha ho etsoa meriana, ho kenyelletsa matlapa le litharollo tsa mahlo, moo tokollo e laoloang le viscosity li leng bohlokoa.
Kaho: Lefapheng la kaho, HPMC e sebelisoa e le motenya lihlahisoa tse thehiloeng ho samente ho ntlafatsa ts'ebetso le ho boloka metsi.
Indasteri ea Lijo: HPMC e sebelisoa e le setenya, se tsitsitseng le emulsifier lits'ebetsong tsa lijo.
The viscosity ea hydroxypropyl methylcellulose ke thepa e rarahaneng e anngoeng ke lintlha tse ngata tse kang boima ba molek'hule, tekanyo ea ho fetola, mahloriso le mocheso. Limaraka tse fapaneng tsa HPMC lia fumaneha ho lumellana le lits'ebetso tse ikhethileng, 'me bahlahisi ba fana ka maqephe a data a botekgeniki a hlalosang mofuta oa viscosity ea sehlopha ka seng tlasa maemo a fapaneng. Bafuputsi le baetsi ba lihlahisoa ba lokela ho nahana ka lintlha tsena ho hlophisa thepa ea HPMC ho fihlela litlhoko tsa lits'ebetso tseo ba li rerileng.
Nako ea poso: Jan-20-2024