Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang le e sebelisoang haholo liindastering tse fapaneng, e tsejoang ka thepa ea eona e ikhethang le ts'ebeliso ea eona. Motsoako ona o tsoa ho cellulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela. Ho utloisisa sebopeho sa hydroxypropylmethylcellulose, hoa hlokahala ho hlahlobisisa sebopeho le motsoako oa motsoako ona oa selulose.
Sebopeho sa cellulose:
Cellulose ke lik'habohaedreite tse rarahaneng tse nang le ketane e lekanang ea li-unit tsa β-D-glucose tse kopantsoeng ke β-1,4-glycosidic bond. Liketane tsena tsa tsoekere li kopantsoe hammoho ke li-hydrogen bond ho etsa sebopeho se thata sa mela. Cellulose ke karolo e ka sehloohong ea sebopeho sa marako a lisele tsa semela, e fanang ka matla le ho tiea ho lisele tsa semela.
Lintho tse tsoang ho Hydroxypropyl Methylcellulose:
Hydroxypropyl methylcellulose e entsoe ka ho fetola selulose ka lik'hemik'hale le ho hlahisa lihlopha tsa hydroxypropyl le methyl ka har'a ketane e kholo ea selulose. Hangata tlhahiso e kenyelletsa mehato e latelang:
Maikutlo a Etherification:
Methylation: Ho phekola cellulose ka tharollo ea alkaline le methyl chloride ho hlahisa lihlopha tsa methyl (-CH3) ka har'a lihlopha tsa hydroxyl (-OH) tsa selulose.
Hydroxypropylation: Methylated cellulose e tsoela pele ho itšoara ka propylene oxide ho hlahisa lihlopha tsa hydroxypropyl (-CH2CHOHCH3) mohahong oa cellulose. Ts'ebetso ena e ntlafatsa ho qhibiliha ha metsi le ho fetola thepa ea 'mele ea selulose.
tlhoekiso:
Selulose e fetotsoeng ebe e hloekisoa ho tlosa li-reagents tse sa sebetseng, lihlahisoa kapa litšila.
Ho omisa le ho sila:
Hydroxypropyl methylcellulose e hloekisitsoeng e omisitsoe ebe e siloa hore e be phofo e ntle e loketseng ho sebelisoa mefuteng e fapaneng ea lisebelisoa.
Lintho tse ka sehloohong tsa Hydroxypropyl Methylcellulose:
Sebopeho sa hydroxypropyl methylcellulose se tšoauoa ka tekanyo ea ho nkela sebaka, e bolelang hore na lihlopha tsa hydroxypropyl le methyl li nka sebaka sa lihlopha tsa hydroxyl ka ketane ea cellulose. Limaraka tse fapaneng tsa HPMC li na le likhato tse fapaneng tsa ho fetola, tse amang solubility ea tsona, viscosity le thepa e 'ngoe.
Mokhoa oa lik'hemik'hale oa hydroxypropyl methylcellulose o ka hlalosoa e le (C6H7O2(OH) 3-mn(OCH3)m(OCH2CH(OH)CH3)n)_x, moo m le n li emelang tekanyo ea ho fetola.
m: tekanyo ea methylation (lihlopha tsa methyl ka yuniti ea tsoekere)
n: tekanyo ea hydroxypropylation (lihlopha tsa hydroxypropyl ka yuniti ea tsoekere)
x: palo ea liyuniti tsa tsoekere ka har'a ketane ea cellulose
Likarolo le Lisebelisoa:
Solubility: HPMC e qhibiliha ka metsing, 'me tekanyo ea ho fetola e ama litšobotsi tsa eona tsa ho qhibiliha. E etsa tharollo e hlakileng le e hlakileng ka metsing, e etsang hore e tšoanelehe bakeng sa mefuta e sa tšoaneng ea metsoako.
Viscosity: The viscosity ea tharollo ea HPMC e itšetlehile ka lintlha tse kang boima ba molek'hule le tekanyo ea ho fetola. Thepa ena e bohlokoa bakeng sa lits'ebetso tse joalo ka litlhare tse hlokang mekhoa e laoloang ea tokollo.
Tlhahiso ea Lifilimi: HPMC e ka etsa lifilimi tse tšesaane ha tharollo e omella, e etsa hore e be molemo ho litlolo liindastering tsa meriana, lijo le tse ling.
Li-Stabilizers and Thickeners: Ka indastering ea lijo, HPMC e sebelisoa e le setepi le se tsitsisa lihlahisoa tse fapaneng, ho kenyeletsoa li-sauces, li-dessert le lintho tse halikiloeng.
Likopo tsa Meriana: HPMC e sebelisoa haholo mekhoeng ea meriana, ho kenyelletsa matlapa, li-capsules, le litharollo tsa mahlo, ka lebaka la thepa ea eona ea tokollo e laoloang le biocompatibility.
Kaho le liphahlo: HPMC e sebelisoa linthong tsa kaho tse joalo ka seretse, likhomaretsi tsa lithaele le lipolasetere. E boetse e sebelisoa e le motenya le stabilizer mefuteng ea pente le ea ho roala.
Lihlahisoa tsa Tlhokomelo ea Motho: Ka indasteri ea litlolo le tlhokomelo ea motho, HPMC e fumanoa lihlahisoa tse kang litlolo, litlolo le li-shampoo, moo e fanang ka sebopeho le botsitso.
Hydroxypropyl methylcellulose e fumanoa ka methylation le hydroxypropylation ea selulose. Ke polymer e nang le merero e mengata e nang le mefuta e mengata ea ts'ebeliso. Thepa ea eona e ikhethang e etsa hore e be ea bohlokoa liindastering tse kang tsa meriana, lijo, kaho le tlhokomelo ea botho. Phetoho e laoloang ea selulose e ka lokisa thepa ea HPMC, ea e etsa karolo ea bohlokoa ea lihlahisoa tse ngata tseo re kopanang le tsona bophelong ba rona ba letsatsi le letsatsi.
Nako ea poso: Jan-10-2024