Hydroxypropyl methyl cellulose HPMC ke eng?

Hydroxypropyl methyl cellulose HPMC ke selulose e seng ionic e tsoakiloeng ka mefuta e fapaneng le ionic methyl carboxymethyl cellulose e tsoakiloeng ether, ha e sebetsane le litšepe tse boima. Li-radicals tse le 'ngoe tsa oksijene ka lebaka la litaba tsa hydroxypropyl methyl cellulose le karolo e fapaneng ea hydroxypropyl content le viscosity, e ile ea fetoha mefuta e fapaneng ea ts'ebetso, mohlala, litaba tse phahameng tsa methoxyl le litaba tse tlase tsa mefuta ea hydroxypropyl, ts'ebetso ea eona e haufi le methyl cellulose le methoxyl e tlase. litaba le litaba tse phahameng tsa mefuta ea hydroxypropyl, mme ts'ebetso ea eona e haufi le hydroxypropyl methyl. cellulose e hlahisoa. Empa ho e 'ngoe le e' ngoe e fapa-fapaneng, le hoja e na le palo e nyenyane feela ea hydroxypropyl kapa e nyenyane ea methoxy, ho qhibiliha ha metsoako ea manyolo kapa mocheso oa flocculation ka tharollo ea metsi, ho na le phapang e kholo.
 
1, ho qhibiliha ha hydroxypropyl methyl cellulose
Hydroxypropyl methyl cellulose ka har'a metsi a hydroxypropyl methyl cellulose ha e le hantle ke mofuta oa propylene oxide (methyl oxypropyl ring) e fetotsoeng methyl cellulose, kahoo e ntse e na le litšobotsi tse tšoanang le tsa methyl cellulose metsi a batang a qhibilihang le litšoaneleho tse sa keneng tsa metsi a chesang. Leha ho le joalo, mocheso oa gelation oa modified hydroxy propyl o phahame haholo ho feta oa methyl cellulose metsing a chesang. Mohlala, viscosity ea hydroxypropyl methylcellulose aqueous solution e nang le 2% methoxy content DS=0.73 le hydroxypropyl content MS=0.46 ke 500 mpa ho 20℃. Thempereichara ea gel ea sehlahisoa sa S e haufi le 100℃, ha ea methyl cellulose ea mocheso o tšoanang e ka ba 55℃ feela. Ha e le solubility ea eona ka metsing, e boetse e ntlafetse haholo, ka mohlala, ka mor'a ho pshatla ha hydroxypropyl methylcellulose (sebopeho sa lijo-thollo 0.2 ~ 0.5mm ka 20 ℃ 4% viscosity ea metsi ea 2pA? Lihlahisoa tsa S li ka qhibiliha habonolo metsing ntle le ho pholile mocheso oa kamore. .
 
(2) Hydroxypropyl methyl cellulose in organic solvents solubility of hydroxypropyl methyl cellulose in organic solvents solubility, hape e betere ho feta methyl cellulose, methyl cellulose e hloka ka tekanyo ea methoxy substitution ea 2.1 kapa ho feta lihlahisoa, 'me e na le hydroxypropyl MS = 1.5 ~ 1.8 le methoxy le methoxy. DS=0.2 ~ 1.0, Viscosity e phahameng hydroxypropyl methyl cellulose e nang le degree ea substitution e kaholimo ho 1.8 e qhibiliha ka methanol ea anhydrous le litharollo tsa ethanol, 'me e na le ho qhibiliha ha thermoplastic le metsi. E boetse e qhibiliha ka har'a li-hydrocarbon tse chlorine joalo ka dichloromethane le trichloromethane, le lihlapolli tsa tlhaho tse kang acetone, joala ba isopropyl le joala ba diacetone. Ho qhibiliha ha eona ka har'a metsoako ea tlhaho ho feta ho qhibiliha ha metsi.
 
2, hydroxypropyl methyl cellulose viscosity ea lintho tse susumetsang
Hydroxypropyl methylcellulose viscosity factor hydroxypropyl methylcellulose standard viscosity determination, and other cellulose ether is the same, are at 20℃ with 2% aqueous solution as the standard determination. The viscosity ea sehlahisoa se tšoanang, ka ho eketseha ha mahloriso le ho eketseha, mahloriso a tšoanang a lihlahisoa tse fapaneng tsa boima ba limolek'hule, boima ba limolek'hule tsa sehlahisoa ke viscosity e phahameng. Kamano ea eona le mocheso e tšoana le ea methyl cellulose. Ha mocheso o phahama, viscosity e qala ho theoha, empa ha e fihla mocheso o itseng, viscosity e phahama ka tšohanyetso 'me gelation e etsahala. Mocheso oa mocheso oa lihlahisoa tse nang le viscosity e tlaase o phahame ho feta oa lihlahisoa tse nang le viscosity e phahameng. Boemo ba ntlha ea gel ea eona, ho phaella ho viscosity e phahameng le e tlaase ea ether, empa hape le karo-karolelano ea lihlopha tsa ether methoxy le hydroxypropyl le tekanyo ea kakaretso ea phetoho e amana. Ho lokela ho hlokomeloa hore hydroxypropyl methylcellulose le eona ke pseudoplastic; tharollo ea eona e tsitsitse ha e bolokiloe mocheso oa kamore 'me ha e bontše ho senyeha ha viscosity ntle le monyetla oa ho senyeha ha enzymatic.
 
3, hydroxypropyl methyl cellulose acid le khanyetso ea alkaline
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid le alkali, ka kakaretso e tsitsitse, ka ph PH2 ~ 12 range ha e amehe, e ka mamella tekanyo e itseng ea acid e khanyang, e kang formic acid, acetic acid, citric acid, succinic acid, phosphoric. acid, boric acid, joalo-joalo Empa acid e concentrated e na le phello ea ho fokotsa viscosity. Alkali e kang caustic soda, potasiamo ea caustic le metsi a kalaka ha e na phello ho eona, empa phello ea ho eketseha ha viscosity ea tharollo e tla fokotseha butle-butle nakong e tlang.
 
4, hydroxypropyl methyl cellulose e ka tsoakoa
Tharollo ea Hydroxypropyl methyl cellulose e ka tsoakoa le metsoako ea polymer e qhibilihang ka metsing, 'me ea fetoha tharollo e ts'oanang e hlakileng e nang le viscosity e phahameng. Lik'hemik'hale tsena tse phahameng tsa limolek'hule ke polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane le hydroxyethyl cellulose le methyl cellulose, joalo-joalo. Metsoako ea tlhaho ea polymer e kang gum Arabic, tsie bean gum, lerenene la sefate sa meutloa joalo-joalo le eona e na le motsoako o motle le eona. tharollo. Hydroxypropyl methyl cellulose e ka boela ea tsoakoa le stearic acid kapa palmitic acid mannitol ester kapa sorbitol ester, empa hape le glycerol, sorbitol le mannitol, metsoako ena e ka sebelisoa e le hydroxypropyl methyl cellulose plasticizer.
 
5, hydroxypropyl methyl cellulose e qhibilihang ka metsing
Hydroxypropyl methyl cellulose insoluble water-soluble cellulose ether, e ka kopana holim'a li-aldehydes, 'me ea etsa hore ether ena e qhibilihang ka metsing e be e qhibilihang ka har'a tharollo, e se ke ea qhibiliha metsing. Le ho etsa hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, joalo-joalo, tšebeliso ea formaldehyde e lokela ho ela hloko ka ho khetheha boleng ba PH ea tharollo, eo ka eona glyoxal e itšoarang ka potlako, kahoo tlhahiso ea indasteri e atisang ho sebelisoa glyoxal e le sefapano. -emedi ya kgokahanyo. Tekanyo ea mofuta ona oa motsoako oa crosslinking ka tharollo ke 0.2% ~ 10% ea boima ba ether, e ntle ka ho fetisisa ke 7% ~ 10%, joalo ka tšebeliso ea glyoxal e nang le 3.3% ~ 6% ke eona e nepahetseng ka ho fetisisa. Kakaretso ea mocheso oa phekolo ke 0 ~ 30 ℃, nako ke 1 ~ 120min. Karabelo ea li-cross-linking e lokela ho etsoa tlas'a maemo a acidic. Ka kakaretso, asiti e matla ea inorganic kapa organic carboxylic acid e eketsoa tharollong ho lokisa PH ea tharollo ho hoo e ka bang 2 ~ 6, haholo-holo lipakeng tsa 4 ~ 6, ebe li-aldehydes lia eketsoa bakeng sa karabelo e kopanyang. Li-acid tse sebelisoang ke hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid kapa citric acid, eo har'a eona e leng formic acid kapa acetic acid e ntle ka ho fetisisa, athe formic acid e le eona e ntle ka ho fetisisa. Li-acids le aldehyde le tsona li ka eketsoa ka nako e le 'ngoe ho lumella tharollo hore e hokahane le mofuta o lakatsehang oa PH. Hangata karabelo ena e sebelisoa ts'ebetsong ea ho qetela ea mokhoa oa ho lokisa cellulose ether, e le hore cellulose ether e se ke ea qhibiliha, ho bonolo ho sebelisa metsi a 20 ~ 25 ℃ ho hlatsoa le ho hloekisa. Ha sehlahisoa se sebelisoa, lintho tsa alkaline li ka kenngoa ho tharollo ea sehlahisoa ho lokisa PH ea tharollo hore e be alkaline, 'me sehlahisoa se qhibiliha ka potlako ka tharollo. Mokhoa ona o ka boela oa sebelisoa ha tharollo ea ether ea cellulose e sebelisoa ho etsa filimi ebe filimi e tšoaroa ho etsa filimi e sa tsitsang.
 
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme khanyetso ea derivatives ea cellulose ka khopolo, joalo ka sehlopha se seng le se seng sa anhydroglucose joalo ka ha ho na le motsoako o tiileng oa lihlopha tse nkang sebaka, khoholeho ea likokoana-hloko ha e kotsing ea tšoaetso, empa ha e le hantle sehlahisoa se felileng se nka sebaka sa boleng bo fetang 1. hape ka ho senyeha ha enzyme, ena ke tlhaloso ea sehlopha se seng le se seng sa tekanyo ea ketane ea cellulose ha e tšoane, Likokoana-hloko li ka khona. e senyeha haufi le lihlopha tsa tsoekere tse sa nkeloeng sebaka ke metsi ho etsa tsoekere, e ka monngoang ke likokoana-hloko e le lijo. Ka hona, haeba tekanyo ea etherification substitution ea selulose e eketseha, ho hanyetsa ha cellulose ether ho khoholeho ea enzymatic ho tla matlafatsoa. Ho tlalehoa hore tlas'a maemo a laoloang, viscosity e setseng ea hydroxypropyl methyl cellulose (DS = 1.9), methyl cellulose (DS = 1.83), methyl cellulose (DS = 1.66), le hydroxyethyl cellulose (1.7%) e ne e le 13.2%, 7.3%. , 3.8%, le 1.7%, ka ho latellana. Hydroxypropyl methyl cellulose e na le matla a matla a anti-enzyme. Ka hona hydroxypropyl methylcellulose e ntle haholo ea anti-enzyme, e kopantsoeng le ho qhalakanngoa ha eona hantle, ho teteka le ho thehoa ha filimi, e sebelisoang ka liphahlo tsa emulsion, joalo-joalo, ka kakaretso ha ho hlokahale ho eketsa li-preservatives. Leha ho le joalo, e le ho thibela ho boloka nako e telele ea tharollo kapa ho ka 'na ha e-ba le tšilafalo e tsoang lefats'eng le ka ntle, li-preservatives li ka eketsoa, ​​tseo khetho ea tsona e ka khethoang ho ea ka litlhoko tsa ho qetela tsa tharollo. Phenylmercuric acetate le manganese fluosilicate ke li-preservatives tse sebetsang, empa li chefo 'me li tlameha ho sebetsoa ka hloko. Ka kakaretso, 1 ~ 5mg phenylmercuric acetate e ka ekeletsoa ho litha e 'ngoe tsa tharollo.
 
7, ts'ebetso ea membrane ea hydroxypropyl methyl cellulose
Ts'ebetso ea filimi ea Hydroxypropyl methyl cellulose ea hydroxypropyl methyl cellulose e na le filimi e ntle haholo, tharollo ea eona ea metsi kapa tharollo ea organic solvent, e koahetsoeng holim'a poleiti ea khalase, ka mor'a ho omisa e fetoha filimi e se nang mebala, e hlakileng le e thata. E na le khanyetso e ntle ea mongobo 'me e lula e tiile mocheso o phahameng. Joalo ka ho eketsoa ha polasetiki ea hygroscopic, e ka ntlafatsa bolelele ba eona le ho feto-fetoha ha maemo, ho ntlafatsa flexure, glycerol le sorbitol le polasetiki e 'ngoe e loketseng ka ho fetisisa. Motsoako oa tharollo e akaretsang ke 2% ~ 3%, tekanyo ea polasetiki ke 10% ~ 20% ea cellulose ether. Haeba litaba tsa plasticizer li le teng, ts'ebetso ea shrinkage ea colloid dehydration e ka etsahala ka mongobo o phahameng. Matla a thata a filimi a ekelitsoeng plasticizer a kholoanyane ho feta a sa kenyelletsoeng, 'me a eketseha ka ho eketseha ha palo ea ho eketsoa, ​​​​ha e le bakeng sa hygroscopicity ea filimi e boetse e eketseha ka ho eketseha ha palo ea polasetiki.