Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e sebelisoang haholo indastering ea meriana. Ke ea sehlopha sa cellulose ether 'me e tsoa ho cellulose ea tlhaho. HPMC e entsoe ka ho phekola selulose ka propylene oxide le methyl chloride, e hlahisang metsoako e nang le ho qhibiliha ho ntlafetseng le lintho tse ling tse lakatsehang. Sehlahisoa sena sa meriana se sebelisoa haholo ho nts'etsopele le ho etsa mefuta e fapaneng ea litekanyetso, ho kenyeletsoa matlapa, li-capsules, litokisetso tsa mahlo le litsamaiso tse laoloang tsa phepelo ea lithethefatsi.
Kenyelletso ea hydroxypropyl methylcellulose:
Sebopeho sa lik'hemik'hale le thepa:
Hydroxypropyl methylcellulose ke semi-synthetic, inert, polymer e qhibilihang ka metsing. Sebopeho sa eona sa lik'hemik'hale se kenyelletsa lihlopha tsa hydroxypropyl le methoxy tse khomaretsoeng mokokotlong oa cellulose. Likarolo tsa likarolo tsena li ka fapana, e leng se etsang hore ho be le limaraka tse fapaneng tsa HPMC e nang le thepa e fapaneng. Mokhoa oa ho fetola o ama likarolo tse kang viscosity, solubility, le thepa ea gel.
Mokhoa oa tlhahiso:
Tlhahiso ea HPMC e kenyelletsa etherification ea cellulose ka propylene oxide le methyl chloride. The degree of substitution (DS) ea hydroxypropyl le lihlopha tsa methoxy li ka laoloa nakong ea ho kopanya, ho lumella ho lokisoa ha thepa ea HPMC ho latela litlhoko tse khethehileng tsa tlhahiso ea lithethefatsi.
Likopo indastering ea meriana:
Li-binders tse entsoeng ka letlapa:
HPMC e sebelisoa haholo joalo ka tlamahano mefuteng ea matlapa. Lintho tsa eona tse tlamang li thusa ho hatella phofo hore e be matlapa a tiileng. Ho lokolloa ho laoloang ha metsoako e sebetsang ea meriana (APIs) ho ka finyelloa ka ho sebelisa limaraka tse itseng tsa HPMC tse nang le viscosity e nepahetseng le maemo a ho fetola.
Moemeli oa ho roala filimi:
HPMC e sebelisoa e le moemeli oa ho roala filimi bakeng sa matlapa le granules. E fana ka seaparo se ts'ireletso se ts'oanang se ntlafatsang ponahalo, ho pata masking le botsitso ba mefuta ea litekanyetso. Ho feta moo, liphahlo tse thehiloeng ho HPMC li ka fetola boemo ba ho lokolloa ha lithethefatsi.
Tokollo e tsitsitseng le e laoloang:
Sebopeho sa hydrophilic ea polymer ena e etsa hore e loketse ho sebelisoa mefuteng e tsitsitseng le e laoloang ea tokollo. Matrix ea HPMC e lumella tokollo ea lithethefatsi e laoloang ka nako e telele, ho ntlafatsa ho latela melao ea mokuli le ho fokotsa khafetsa ea dosing.
Litokiso tsa Ophthalmic:
Ka mekhoa ea mahlo, HPMC e sebelisoa ho eketsa viscosity ea marotholi a mahlo, kahoo e fana ka nako e telele ea ho lula sebakeng sa mahlo. Sena se matlafatsa bioavailability ea moriana le katleho ea kalafo.
Thickening stabilizer:
HPMC e sebelisoa e le motenya le stabilizer linthong tse mokelikeli le halofo tse tiileng tse kang li-gel, litlolo le li-suspensions. E fana ka viscosity ho metsoako ena le ho ntlafatsa thepa ea bona ea rheological ka kakaretso.
Lintlha tsa bohlokoa tsa HPMC:
Sollubility:
HPMC e qhibiliha ka metsing 'me e etsa tharollo e hlakileng, e se nang mebala. Sekhahla sa ho qhibiliha se angoa ke tekanyo ea ho fetola le boemo ba viscosity.
Viscosity:
Viscosity ea tharollo ea HPMC ke ea bohlokoa ho khethollang ts'ebetso ea bona lits'ebetsong tse fapaneng. Limaraka tse fapaneng li fumaneha ka li-viscosity tse fapaneng, tse lumellang taolo e nepahetseng ea thepa ea rheological ea sebopeho.
Thermal gelation:
Limaraka tse ling tsa HPMC li bonts'a thepa ea thermogelling, li etsa li-gel ka mocheso o phahameng. Thepa ena e sebelisetsoa ho etsa litlolo tse thibelang mocheso.
lumellana:
HPMC e sebelisana le mefuta e mengata e fapaneng ea li-excipients tsa meriana le li-API, e leng se etsang hore e be khetho ea pele bakeng sa baetsi ba lihlahisoa. Ha e sebetsane le kapa ho theola metsoako e mengata e sebetsang.
Mathata le maikutlo:
Hygroscopicity:
HPMC ke hygroscopic, ho bolelang hore e monya mongobo o tsoang tikolohong. Sena se ama botsitso le ponahalo ea sebopeho, kahoo ho hlokahala maemo a nepahetseng a polokelo.
Ho lumellana le li-excipients tse ling:
Le hoja ka kakaretso e lumellana, baetsi ba lihlahisoa ba hloka ho nahana ka ho lumellana ha HPMC le lisebelisoa tse ling ho qoba litšebelisano tse ka 'nang tsa ama ts'ebetso ea tlhahiso.
Phello ho curve ea dissolution:
Khetho ea sehlopha sa HPMC e ka ama haholo boemo ba ho felisoa ha moriana. Moetsi o tlameha ho khetha ka hloko kereiti e loketseng ho fihlela litšobotsi tse lakatsehang tsa tokollo.
Mehaho ea taolo:
HPMC e amoheloa ke batho ba bangata e le sesebelisoa sa meriana se sireletsehileng le se sebetsang. E kopana le litekanyetso tse fapaneng tsa taolo mme e kenyelelitsoe ho li-pharmacopoeia ho pota lefatše. Baetsi ba tlameha ho latela Mekhoa e Metle ea Tlhahiso (GMP) ho netefatsa boleng le botsitso ba lihlahisoa tsa meriana tse nang le HPMC.
ha re phethela:
Hydroxypropylmethylcellulose (HPMC), joalo ka sethusi se feto-fetohang le se sebelisoang haholo, se bapala karolo ea bohlokoa indastering ea meriana. Thepa ea eona e ikhethang e etsa hore e loketse ho sebelisoa ka mefuta e fapaneng ea litekanyetso, ho kenyeletsoa matlapa, li-capsules le litokisetso tsa ophthalmic. Baetsi ba liforomo ba rua molemo ka ho khona ho lokisa thepa ea HPMC ho fihlela litlhoko tse khethehileng tsa ho hlophisoa, joalo ka tokollo e laoloang le botsitso bo ntlafalitsoeng. Ho sa tsotellehe mathata a mang, HPMC e ntse e le motsoako oa bohlokoa ho nts'etsopele ea lihlahisoa tsa meriana tsa boleng bo phahameng, tse tlatsetsang polokehong le katlehong ea litlhare tse ngata tsa meriana.
Nako ea poso: Dec-15-2023