Hydroxypropyl Methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang liindastering tse fapaneng ho kenyelletsa le meriana, kaho, lijo le litlolo.E tsoa ho cellulose, polima ea tlhaho e fumanoang limela.HPMC e ananeloa haholo bakeng sa thepa ea eona ea ho etsa lifilimi, ho tiisa, ho tsitsisa le ho boloka metsi.Indastering ea meriana, hangata e sebelisoa e le mothusi oa meriana mefuteng ea litekanyetso tsa molomo, litokisetso tsa mahlo, li-topical formulations, le litsamaiso tse laoloang tsa phano ea lithethefatsi.
HPMC e ka hlophisoa ho ipapisitsoe le liparamente tse 'maloa ho kenyeletsoa boima ba limolek'hule, tekanyo ea ho fetola, le boholo ba likaroloana.Mona ke kakaretso ea mefuta e fapaneng ea HPMC e ipapisitseng le liparamente tsena:
E ipapisitse le Boima ba Molek'hule:
High Molecular Weight HPMC: Mofuta ona oa HPMC o na le boima bo phahameng ba molek'hule, bo lebisang ho ntlafatso ea viscosity le thepa ea ho etsa lifilimi.Hangata e ratoa lits'ebetsong moo ho hlokahalang viscosity e phahameng, joalo ka litlhophiso tsa tokollo e laoloang.
Low Molecular Weight HPMC: Ka lehlakoreng le leng, boima bo tlase ba molek'hule HPMC e na le viscosity e tlase mme e sebelisoa lits'ebetsong moo ho batloang viscosity e tlase le ho qhibiliha ka potlako.
Ho ipapisitsoe le Degree of Substitution (DS):
High Substitution HPMC (HPMC-HS): HPMC e nang le tekanyo e phahameng ea ho fetola hangata e bonts'a ho qhibiliha ho betere ka metsing 'me e ka sebelisoa ho metsoako e hlokang ho qhibiliha ka potlako.
Medium Substitution HPMC (HPMC-MS): Mofuta ona oa HPMC o fana ka tekanyo pakeng tsa solubility le viscosity.E atisa ho sebelisoa mefuteng e sa tšoaneng ea meriana.
Low Substitution HPMC (HPMC-LS): HPMC e nang le tekanyo e tlase ea sebaka e fana ka litekanyetso tse liehang tsa ho qhibiliha le viscosity e phahameng.Hangata e sebelisoa ka mokhoa o tsitsitseng oa tokollo ea litekanyetso.
E ipapisitse le Boholo ba Karolo:
Fine Particle Size HPMC: HPMC e nang le boholo bo nyane ba karoloana e fana ka thepa ea phallo e betere mme hangata e ratoa ka mefuta e tiileng ea litekanyetso tse joalo ka matlapa le li-capsules.
Coarse Particle Size HPMC: Likaroloana tse Coarser li loketse lits'ebetso moo ho batloang thepa e laoloang kapa tokollo e atolositsoeng.Hangata li sebelisoa matlapeng a matrix le li-pellets.
Mephato e Ikgethileng:
Enteric HPMC: Mofuta ona oa HPMC o entsoe ka mokhoa o khethehileng ho hanela mokelikeli oa gastric, o o nolofalletsa ho feta ka mpeng o ntse o le teng le ho lokolla moriana ka maleng.E sebelisoa hangata bakeng sa lithethefatsi tse utloang pH ea ka mpeng kapa bakeng sa ho fana ka sepheo.
Sustained Release HPMC: Metsoako ena e etselitsoe ho lokolla motsoako o sebetsang butle-butle ka nako e telele, e lebisang ts'ebetsong ea nako e telele ea lithethefatsi le ho fokotsa makhetlo a mangata.Hangata li sebelisoa maemong a sa foleng moo ho boloka maemo a kamehla a lithethefatsi maling ho leng bohlokoa.
Mephato e Kopanetsweng:
HPMC-Acetate Succinate (HPMC-AS): Mofuta ona oa HPMC o kopanya thepa ea HPMC le lihlopha tsa acetyl, e leng se etsang hore e tšoanelehe bakeng sa liphahlo tsa enteric le mekhoa ea ho fana ka lithethefatsi e nang le pH-sensitive.
HPMC-Phthalate (HPMC-P): HPMC-P ke polima e itšetlehileng ka pH e atisang ho sebelisoa liphahlong tsa enteric ho sireletsa moriana ho tloha maemong a asiti ka mpeng.
Metsoako e ikhethileng:
Baetsi ba ka theha motsoako o ikhethileng oa HPMC le lipolymer tse ling kapa li-excipients ho fihlela litlhoko tse ikhethileng tsa sebopeho joalo ka liprofaele tse ntlafalitsoeng tsa tokollo ea lithethefatsi, botsitso bo ntlafalitsoeng, kapa thepa e ntle ea ho pata tatso.
mefuta e fapaneng ea thepa ea HPMC e lumella hore e sebelisoe mefuteng e mengata ea metsoako ea meriana, e 'ngoe le e' ngoe e etselitsoe ho finyella litlhoko tse khethehileng tse kang solubility, viscosity, kinetics ea ho lokolla, le botsitso.Ho utloisisa mefuta e fapaneng ea HPMC le litšoaneleho tsa eona ho bohlokoa hore baetsi ba lihlahisoa ba rale mekhoa e sebetsang hantle le e ntlafalitsoeng ea phano ea lithethefatsi.
Nako ea poso: Mar-19-2024