Hydroxypropyl methylcellulose (HPMC) ke motsoako o sebelisoang ka tloaelo oa polymer, o sebelisoang haholo ho haha, meriana, lijo le liindasteri tse ling. Joalo ka polima e qhibilihang ka metsing, HPMC e na le ts'ebetso e ntle ea ho boloka metsi, ho etsa filimi, ho tiisa le ho etsa emulsifying. Ho boloka metsi a eona ke e 'ngoe ea litšobotsi tsa eona tsa bohlokoa lits'ebetsong tse ngata, haholo-holo ka thepa e kang samente, seretse le lirafshoa indastering ea kaho, tse ka liehisang ho tsoa mouoane oa metsi le ho ntlafatsa ts'ebetso ea kaho le boleng ba sehlahisoa sa ho qetela. Leha ho le joalo, ho boloka metsi ha HPMC ho amana haufi-ufi le phetoho ea mocheso tikolohong e ka ntle, 'me ho utloisisa kamano ena ho bohlokoa bakeng sa ts'ebeliso ea eona likarolong tse fapaneng.
1. Sebopeho le poloko ea metsi ea HPMC
HPMC e entsoe ka phetoho ea lik'hemik'hale ea selulose ea tlhaho, haholo-holo ka ho kenngoa ha lihlopha tsa hydroxypropyl (-C3H7OH) le methyl (-CH3) ka har'a ketane ea cellulose, e fanang ka thepa e ntle ea solubility le taolo. Lihlopha tsa hydroxyl (-OH) limolek'hule tsa HPMC li ka theha likamano tsa haedrojene ka limolek'hule tsa metsi. Ka hona, HPMC e ka monya metsi 'me ea kopana le metsi, e bontša ho boloka metsi.
Ho boloka metsi ho bolela bokhoni ba ntho ea ho boloka metsi. Bakeng sa HPMC, e bonahala haholo-holo ka bokhoni ba eona ba ho boloka metsi ka har'a tsamaiso ka hydration, haholo-holo mocheso o phahameng kapa maemo a mongobo a phahameng, a ka thibelang ho lahleheloa ke metsi ka potlako le ho boloka ho koloba ha ntho. Kaha hydration ka limolek'hule tsa HPMC e amana haufi-ufi le tšebelisano ea sebopeho sa eona sa molek'hule, liphetoho tsa mocheso li tla ama ka ho toba matla a ho monya metsi le ho boloka metsi a HPMC.
2. Phello ea mocheso ho boloka metsi a HPMC
Kamano pakeng tsa ho boloka metsi ea HPMC le mocheso ka tšohloa likarolong tse peli: e 'ngoe ke phello ea mocheso ka solubility ea HPMC,' me e 'ngoe ke phello ea mocheso sebopeho sa eona sa molek'hule le hydration.
2.1 Phello ea mocheso ho solubility ea HPMC
The solubility ea HPMC ka metsing e amana le mocheso. Ka kakaretso, solubility ea HPMC e eketseha ka mocheso o ntseng o eketseha. Ha mocheso o phahama, limolek'hule tsa metsi li fumana matla a eketsehileng a mocheso, e leng se bakang ho fokolisa tšebelisano pakeng tsa limolek'hule tsa metsi, kahoo li khothalletsa ho qhibiliha. HPMC. Bakeng sa HPMC, ho eketseha ha mocheso ho ka etsa hore ho be bonolo ho theha tharollo ea colloidal, kahoo ho matlafatsa ho boloka metsi ka metsing.
Leha ho le joalo, mocheso o phahameng haholo o ka eketsa viscosity ea tharollo ea HPMC, e amang thepa ea eona ea rheological le dispersibility. Le hoja phello ena e ntle bakeng sa ntlafatso ea solubility, mocheso o phahameng haholo o ka fetola botsitso ba sebopeho sa eona sa limolek'hule 'me oa lebisa ho fokotseha ha metsi.
2.2 Phello ea mocheso mohahong oa limolek'hule oa HPMC
Sebopeho sa limolek'hule tsa HPMC, li-hydrogen bond li thehoa haholo-holo ka limolek'hule tsa metsi ka lihlopha tsa hydroxyl, 'me tlamo ena ea hydrogen e bohlokoa ho boloka metsi a HPMC. Ha mocheso o ntse o eketseha, matla a bond ea haedrojene a ka 'na a fetoha, a fella ka ho fokotseha ha matla a tlamang pakeng tsa molek'hule ea HPMC le molek'hule ea metsi, kahoo a ama ho boloka metsi. Ka ho khetheha, ho eketseha ha mocheso ho tla etsa hore maqhama a hydrogen a molek'hule ea HPMC a arohane, kahoo a fokotsa ho monya ha metsi le ho boloka metsi.
Ho phaella moo, boikutlo ba mocheso oa HPMC bo boetse bo bontšoa boitšoarong ba mohato oa tharollo ea eona. HPMC e nang le litekanyo tse fapaneng tsa limolek'hule le lihlopha tse fapaneng tse fapaneng li na le maikutlo a fapaneng a mocheso. Ka kakaretso, boima bo tlase ba limolek'hule HPMC e na le kutloelo-bohloko ho mocheso, ha boima bo phahameng ba limolek'hule HPMC bo bontša ts'ebetso e tsitsitseng haholoanyane. Ka hona, lits'ebetsong tse sebetsang, hoa hlokahala ho khetha mofuta o nepahetseng oa HPMC ho latela mofuta o ikhethileng oa mocheso ho netefatsa ho bolokoa ha metsi mochesong o sebetsang.
2.3 Phello ea mocheso holim'a mouoane oa metsi
Sebakeng sa mocheso o phahameng oa mocheso, ho bolokoa ha metsi ha HPMC ho tla angoa ke mouoane o potlakileng oa metsi o bakoang ke ho eketseha ha mocheso. Ha mocheso oa kantle o phahame haholo, metsi a tsamaisong ea HPMC a ka fetoha mouoane. Leha HPMC e ka boloka metsi ho isa bohōleng bo itseng ka sebopeho sa eona sa limolek'hule, mocheso o phahameng haholo o ka etsa hore sistimi e lahleheloe ke metsi ka potlako ho feta matla a ho boloka metsi a HPMC. Tabeng ena, ho boloka metsi a HPMC ho thibetsoe, haholo-holo mocheso o phahameng le tikoloho e omileng.
Ho fokotsa bothata bona, liphuputso tse ling li bontšitse hore ho eketsa li-humectants tse loketseng kapa ho fetola likarolo tse ling ka foromo ho ka ntlafatsa phello ea ho boloka metsi ea HPMC sebakeng sa mocheso o phahameng. Ka mohlala, ka ho fetola mofetoleli oa viscosity ka foromo kapa ho khetha mokelikeli o fokolang o fokolang, ho boloka metsi a HPMC ho ka ntlafatsoa ho isa bohōleng bo itseng, ho fokotsa phello ea ho eketseha ha mocheso holim'a mouoane oa metsi.
3. Lintho tse susumetsang
Phello ea mocheso ho boloka metsi a HPMC ha e itšetlehe feela ka mocheso o potolohileng ka boeona, empa hape le boima ba limolek'hule, tekanyo ea ho fetola, mahloriso a tharollo le lintlha tse ling tsa HPMC. Ka mohlala:
Boima ba molek'hule:HPMC ka boima bo phahameng ba limolek'hule hangata bo na le ho boloka metsi a matla, hobane sebopeho sa marang-rang se entsoeng ke liketane tse phahameng tsa boima ba limolek'hule ka tharollo li ka monya le ho boloka metsi ka katleho.
Degree of substitution: Tekanyo ea methylation le hydroxypropylation ea HPMC e tla ama tšebelisano ea eona le limolek'hule tsa metsi, kahoo e ama ho boloka metsi. Ha re bua ka kakaretso, boemo bo phahameng ba ho nka sebaka bo ka ntlafatsa hydrophilicity ea HPMC, ka hona, ho ntlafatsa ho boloka metsi.
Khatiso ea Tharollo: Boiketlo ba HPMC bo boetse bo ama ho boloka metsi ho eona. Litharollo tse phahameng tsa HPMC hangata li na le litlamorao tse ntle tsa ho boloka metsi, hobane HPMC e phahameng e ka boloka metsi ka ho sebelisana ho matla ha limolek'hule.
Ho na le kamano e rarahaneng pakeng tsa ho boloka metsi aHPMCle mocheso. Mocheso o eketsehileng hangata o khothalletsa ho qhibiliha ha HPMC 'me ho ka lebisa ho ntlafatseng ho boloka metsi, empa mocheso o phahameng haholo o tla senya sebopeho sa limolek'hule tsa HPMC, ho fokotsa matla a eona a ho tlama metsi, kahoo ho ama phello ea ho boloka metsi. E le ho finyella ts'ebetso e ntle ka ho fetisisa ea ho boloka metsi tlas'a maemo a fapaneng a mocheso, hoa hlokahala ho khetha mofuta o nepahetseng oa HPMC ho latela litlhoko tse khethehileng tsa kopo le ho fetola maemo a tšebeliso ea eona ka mokhoa o utloahalang. Ntle le moo, likarolo tse ling tsa maano le maano a taolo ea mocheso li ka boela tsa ntlafatsa ho bolokoa ha metsi a HPMC maemong a mocheso o phahameng ho isa tekanyong e itseng.
Nako ea poso: Nov-11-2024