Hydroxypropylmethylcellulose (HPMC) ke phetoho ea maiketsetso ea selulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela. Le hoja HPMC ka boeona e se biopolymer ka ho feletseng kaha e entsoe ka lik'hemik'hale, hangata e nkoa e le semi-Synthetic kapa modified biopolymers.
A. Kenyelletso ea hydroxypropyl methylcellulose:
Hydroxypropyl methylcellulose (HPMC):
Hydroxypropylmethylcellulose (HPMC) ke e nkiloeng ho selulose, polymer e melang e entsoeng ka likarolo tsa tsoekere. Cellulose ke karolo ea mantlha ea sebopeho sa marako a lisele tsa semela. HPMC e entsoe ka ho fetola selulose ka lik'hemik'hale ka ho eketsa lihlopha tsa hydroxypropyl le methyl.
B. Sebopeho le tshebetso:
1. Sebopeho sa lik'hemik'hale:
Sebopeho sa lik'hemik'hale sa HPMC se na le likarolo tsa mokokotlo oa cellulose tse nang le hydroxypropyl le lihlopha tsa methyl. Degree of substitution (DS) e bolela palo e tloaelehileng ea lihlopha tsa hydroxypropyl le methyl ka yuniti ea tsoekere ka har'a ketane ea cellulose. Phetoho ena e fetola thepa ea 'mele le ea lik'hemik'hale ea selulose, e hlahisang mefuta e mengata ea limaraka tsa HPMC tse nang le li-viscosity tse sa tšoaneng, solubility le thepa ea gel.
2. Thepa ea 'mele:
Solubility: HPMC e qhibiliha ka metsing 'me e etsa litharollo tse hlakileng, e leng se etsang hore e be motsoako oa bohlokoa lits'ebetsong tse fapaneng tse kenyeletsang meriana, lijo le kaho.
Viscosity: Viscosity ea tharollo ea HPMC e ka laoloa ka ho fetola tekanyo ea ho fetola le boima ba molek'hule ea polymer. Thepa ena e bohlokoa bakeng sa lits'ebetso tse joalo ka litlhare tsa meriana le lisebelisoa tsa kaho.
3. Mosebetsi:
Thickeners: HPMC e atisa ho sebelisoa e le setenya lijong, meriana, le lihlahisoa tsa tlhokomelo ea botho.
Ho Etsa Lifilimi: E ka etsa lifilimi 'me e ka sebelisoa ho koahela matlapa a meriana le li-capsules, hammoho le ho hlahisa lifilimi bakeng sa mefuta e fapaneng ea lisebelisoa.
Poloko ea Metsi: HPMC e tsebahala ka thepa ea eona ea ho boloka metsi, e thusa ho ntlafatsa ts'ebetso le ho fana ka metsi a thepa ea moaho joalo ka lihlahisoa tse thehiloeng ho samente.
C. Tšebeliso ea HPMC:
1. Lithethefatsi:
Ho roala Letlapa: HPMC e sebelisetsoa ho etsa liphahlo tsa letlapa ho laola ho lokolloa ha lithethefatsi le ho ntlafatsa botsitso.
Phano ea lithethefatsi ka molomo: The biocompatibility le thepa ea tokollo e laoloang ea HPMC e etsa hore e tšoanelehe bakeng sa litsamaiso tsa phepelo ea lithethefatsi tsa molomo.
2.Indasteri ea kaho:
Lihlahisoa tsa Seretse le Samente: HPMC e sebelisoa ho thepa ea kaho ho ntlafatsa ho boloka metsi, ho sebetsa le ho khomarela.
3. Indasteri ea lijo:
Li-Thickeners le Stabilizers: HPMC e sebelisoa e le setsi se matla le se tsitsitseng lijong ho ntlafatsa sebopeho le botsitso.
4. Lihlahisoa tsa tlhokomelo ea motho ka mong:
Tlhahiso ea Litlolo: HPMC e kenyelelitsoe mefuteng ea litlolo bakeng sa thepa ea eona ea ho etsa filimi le ho tenya.
5. Lipente le Liaparo:
Liaparo tse nang le metsi: Ka indasteri ea ho roala, HPMC e sebelisoa ho hlahisa metsi ho ntlafatsa rheology le ho thibela pigment ho rarolla.
6. Maikutlo a tikoloho:
Le hoja HPMC ka boeona e se polima e ka senyehang ka ho feletseng, tšimoloho ea eona ea cellulosic e etsa hore e senyehe ha e bapisoa le li-polymer tse entsoeng ka ho feletseng. HPMC e ka senyeha ka tlas'a maemo a itseng, 'me tšebeliso ea eona mekhoeng e tsitsitseng le e ka senyehang ke sebaka sa lipatlisiso tse tsoelang pele.
Hydroxypropylmethylcellulose (HPMC) ke polymer ea semi-synthetic e sebetsang ka bongata e nkiloeng ho selulose. Thepa ea eona e ikhethang e etsa hore e be ea bohlokoa liindastering tse fapa-fapaneng tse kenyeletsang meriana, kaho, lijo, tlhokomelo ea botho le pente. Leha e se mofuta o hloekileng ka ho fetesisa oa biopolymer, tšimoloho ea eona ea selulose le bokhoni ba ho senyeha ha bioloji li tsamaellana le tlhoko e ntseng e hola ea lisebelisoa tse tšoarellang haholoanyane lits'ebetsong tse fapaneng. Patlisiso e ntseng e tsoela pele e ntse e tsoela pele ho hlahloba mekhoa ea ho ntlafatsa tšebelisano ea tikoloho ea HPMC le ho holisa ts'ebeliso ea eona mekhoeng e baballang tikoloho.
Nako ea poso: Feb-07-2024