Hydroxypropylmethylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang. Motsoako ona o tsoa ho cellulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela. Tšimoloho ea HPMC e kenyelletsa ho phekola cellulose ka propylene oxide ho hlahisa lihlopha tsa hydroxypropyl le methyl chloride ho hlahisa lihlopha tsa methyl. Polymer e hlahisoang e bonts'a mefuta e mengata ea thepa ea 'mele le ea lik'hemik'hale, e etsa hore e loketse ho sebelisoa liindasteri tsa meriana, tsa kaho, tsa lijo le tse ling.
1. Sebopeho sa lik'hemik'hale le sebopeho:
Hydroxypropyl methylcellulose ke polymer ea semi-synthetic e nang le sebopeho se rarahaneng sa lik'hemik'hale. Mokokotlo oa polymer o na le selulose, ketane e lekanang ea limolek'hule tsa tsoekere e hokahantsoeng ke β-1,4-glycosidic bond. Sehlopha sa hydroxypropyl se hlahisoa ka ho nkela sehlopha sa hydroxyl (-OH) sebaka ka sehlopha sa propyl, 'me sehlopha sa methyl se hlahisoa ka mokhoa o ts'oanang. The degree of substitution (DS) e emetse palo e tloaelehileng ea lihlopha tsa hydroxypropyl le methyl ho yuniti ea tsoekere 'me e ama ho solubility, viscosity, le thepa ea mocheso ea polymer.
2. Sollubility:
E 'ngoe ea likarolo tse ikhethang tsa HPMC ke boitšoaro ba eona ba ho qhalana. E qhibiliha ka metsing a batang le a chesang, e fana ka melemo e ikhethang ka mefuta e fapaneng ea lisebelisoa. Solubility e ka fetoloa ka ho fetola tekanyo ea ho fetola le boima ba limolek'hule tsa polymer. Thepa ena e etsa hore HPMC e be mokhethoa ea hloahloa bakeng sa lits'ebetso tse laoloang tsa phepelo ea lithethefatsi, moo sekhahla sa ho qhala se bapalang karolo ea bohlokoa ho kinetics ea tokollo ea lithethefatsi.
3. Viscosity:
Hydroxypropyl methylcellulose e fumaneha ka mefuta e sa tšoaneng ea viscosity, ho itšetlehile ka lintlha tse kang boima ba molek'hule, tekanyo ea ho fetola, le ho tsepamisa mohopolo oa tharollo. Viscosity ea tharollo ea HPMC e li lumella hore li sebelisoe lits'ebetsong tse ngata tsa indasteri, ho kenyeletsoa le meriana, e le li-thickeners ka mefuta ea litekanyetso tsa mokelikeli, le joalo ka lisebelisoa tsa ho etsa lifilimi bakeng sa ho roala.
4. Ts'ebetso ea ho etsa lifilimi:
Bokhoni ba ho etsa lifilimi ba HPMC bo bohlokoa haholo lits'ebetsong tse kang ho roala lithethefatsi, moo ho sebelisetsoang ho fana ka lera le sireletsang ho pata tatso ea lithethefatsi, ho laola ho lokolloa ha lithethefatsi, le ho ntlafatsa botsitso. Lifilimi tsa HPMC li hlakile ebile lia tenyetseha, 'me thepa ea tsona e ka hlophisoa ka ho lokisa mahloriso a polymer, boima ba limolek'hule le litaba tsa polasetiki.
5. Ts'ebetso ea mocheso:
Hydroxypropyl methylcellulose e bonts'a botsitso bo botle ba mocheso ka har'a mefuta e itseng ea mocheso. Thermal properties angoa ke lintlha tse kang tekanyo ea ho fetola, boima ba molek'hule, le boteng ba li-plasticizers. Thepa ena e etsa hore HPMC e loketse lits'ebetso moo botsitso ba mocheso bo leng bohlokoa haholo, joalo ka ho lokisoa ha metsoako ea meriana e sa utloeng mocheso.
6. Biocompatibility:
Makaleng a meriana le a biomedical, biocompatibility ke taba ea bohlokoa bakeng sa lisebelisoa tse sebelisoang lits'ebetsong tsa phepelo ea lithethefatsi. Hydroxypropyl methylcellulose ka kakaretso e nkuoa e bolokehile ebile e na le biocompatibility e ntle. E sebelisoa haholo ha ho etsoa liforomo tsa litekanyetso tsa molomo, litharollo tsa mahlo le mekhoa e laoloang ea ho fana ka lithethefatsi.
7. Ho boloka metsi le ho tenya:
Bokhoni ba HPMC ba ho boloka metsi le litharollo tsa botenya bo etsa hore e be ea bohlokoa ho thepa ea kaho joalo ka lihlahisoa tse thehiloeng ho samente. Lits'ebetsong tsena, HPMC e sebetsa e le sesebelisoa sa ho boloka metsi, ho ntlafatsa ts'ebetso le ho thibela ho omisoa ha thepa pele ho nako. Lintho tse teteaneng li boetse li sebelisoa lihlahisoa tse fapaneng tsa lijo ho matlafatsa sebopeho le molomo.
8. Phano ea lithethefatsi tse laoloang:
E 'ngoe ea ts'ebeliso ea bohlokoa ea hydroxypropyl methylcellulose ke ho thehoeng ha litsamaiso tsa phepelo ea lithethefatsi tse laoloang. Ho solubility ha polymer, viscosity, le thepa ea ho etsa lifilimi li thusa ho lokolloa ha lithethefatsi ka mokhoa o laoloang, ho nolofalletsa phepelo ea lithethefatsi e tšoarellang le e reretsoeng. Sena se molemo ka ho khetheha bakeng sa ho ntlafatsa ho mamela mokuli le ho fokotsa litla-morao tse amanang le ho lokolloa ha lithethefatsi ka potlako.
9. Ho tsitsisa tlasa maemo a fapaneng a pH:
HPMC e bontša botsitso holim'a mefuta e mengata ea pH, e etsa hore e tšoanelehe bakeng sa metsoako e hlokang botsitso tlas'a maemo a asiti kapa a alkaline. Thepa ena e na le molemo ho litlhare hobane litlhare li ka kopana le maemo a fapaneng a pH ka har'a pampiri ea mala.
10. Lintho tsa Rheological:
Boitšoaro ba rheological ba tharollo ea HPMC bo bohlokoa bakeng sa lits'ebetso moo thepa ea phallo e leng bohlokoa haholo, joalo ka ha ho lokisoa lirafshoa, likhomaretsi le ligel. Thepa ea rheological e ka hlophisoa ka ho lokisa mahloriso le boima ba limolek'hule tsa HPMC ho fihlela litšobotsi tsa phallo tse hlokahalang bakeng sa taolo e nepahetseng ea elektronike.
Hydroxypropyl methylcellulose e fetohile polymer ea bohlokoa haholo liindastering tse fapaneng ka lebaka la motsoako oa eona o ikhethang oa solubility, viscosity, bokhoni ba ho etsa lifilimi le biocompatibility. Ho feto-fetoha ha eona ho etsa hore e tšoanelehe bakeng sa lisebelisoa tse fapaneng, ho tloha ho meriana le thepa ea kaho ho ea lijong le litlolo. Ha bafuputsi ba ntse ba tsoela pele ho hlahloba mekhoa le lisebelisoa tse ncha, thepa ea hydroxypropyl methylcellulose ha ho pelaelo hore e tla kenya letsoho ntlafatsong ea likarolo tse fapaneng, ho netefatsa bohlokoa ba eona bo tsoelang pele ho saense ea thepa le indasteri.
Nako ea poso: Jan-10-2024