HydroxypropypropyLese (HPMC)
Sehlopha: lisebelisoa tsa koae; Thepa ea membrane; Lisebelisoa tse laoloang ka potlako bakeng sa litokisetso tsa ho lokolla butle; Moemeli; Thuso ea ho emisoa, hodhenive ea matla le matla; Kholiseho e matlafatsang.
1. Selelekela sa sehlahisoa
Sehlahisoa sena ke sesebelisoa se seng sa Ioni sa IoniL Cellulose, se bonoang ka metsing, se nang le li-solvent tse batang, tse rutehang ka metsing a batang. Tharollo ea mahlo e na le ketsahalo e kaholimo, litlhaloso tse phahameng le tse tsitsitseng. HPMC e na le thepa ea gel e chesang e chesang. Kamora ho futhumatsa, tharollo ea sehlahisoa se halefileng sehlahisoa se theha seriti sa sekhukhu, ebe se qhibiliha ka mor'a ho fola. Mocheso oa rul oa litlhaloso tse fapaneng o fapane. Liphetoho tsa SELUBIL le Viscosity, Viscossity Zhao Low, Lipapali tse kholo
Mocheso o ikhethileng, o pheteloang ke matla a ikhethileng, letsoalo la ho feto-fetoha le 'nete le mocheso oa khalase e ne e le 360 ℃, 1.326g / 170 ℃, ka ho latellana. Kamora ho futhumatsa, e fetoha sopi ka 190 ~ 200 ° C le Burns ho 225 ~ 230 zest ° C.
HPMC e batla e sa khathatseheng Chloroform, Ethanol (95%), motsoako oa Methanol le Methylene Chride, le motsoako oa metsi le mathtol. Mekhahlelo e meng ea HPMC e qhibilisoa ka bongata ba acetone, Methylene Chride, le ea 2 - pokello ea mantsoe a mang a manyolo.
Tafole 1: Matšoao a botekgeniki
Morero
Lekala,
60 gd (2910).
65GD (2906)
75GD (2208)
Mekhoa%
28.0-32.0
27.0-30.0
19.0-24.0
Hydroxypropoxy%
7.0-12.0
4.0-7.5
4.0-12.0
Mocheso oa Gel ℃
56-64.
62.0-68.0
70.0-90.0
Viscosture mpa s.
3,5,6,15,15,15,4000
50400 000 0
100400 0150 00100 000
Tahlehelo ea Boikemisetso bo omeletseng%
5.0 kapa ka tlase
Ho chesa%
1.5 kapa ka tlase
pH
4.0-8.0
Tšepe e boima
20 kapa ka tlase
arnic
2.0 kapa ka tlase
2. Likarolo tsa sehlahisoa
2.1 hydroxypropyproppyl methylcelulose e qhibiliha ka metsing a batang ho etsa tharollo ea lirifi. Hafeela e eketsoa ka metsing a batang le ho hlasimoha hanyane, ho ka qhibiliha ho rarolla tharollo ea tšoaetso. Ho fapana le moo, ha e le hantle e sa khathatse ka metsing a chesang ka holim'a 60 ℃ mme e ka ruruha feela. Thapeli ea HydroxypropyLe methicelluse ea afquous, ho molemo ho eketsa karolo ea 'mele, e futhumatsang methroxyproplaylule,' me qetellong sebelisa metsi a batang ho tlatlapa ho isa tekanyong e hlokahalang.
2.2 hydroxypropyLe methylcelulose tlhahiso.
2.3 HydroxyproPypropinyL methylceluse e na le khatello e matla ea khatello ea maikutlo, le ka keketseho ea boemo ba limoleke, khatello ea maikutlo le eona e ntlafatsoe. Lithethefatsi li sebelisa HPMC e le ho li tsebisa lintho tse tsitsitseng ka nako e sebetsang ho feta lithethefatsi li sebelisa litšoaneleho tse ling tsa setso (starch, tsoekere e tsoekere).
2.4 hydroxypropyproppyl methylcelulose ka methylilose ka mohopolo. E le meriana ea meriana, ha se metabolsopler kapa monyaki, kahoo ha e fane ka mocheso meriana le meriana. E na le tokelo e ikhethang ho ho fokotsa boleng ba caloric, lithethefatsi le lijo tse se nang litsie le lijo tsa lefu la tsoekere.
2.5hpmc e tiisitsoe haholo ho acid le li-phs, empa haeba pH e feta 2 ~ 11 Nako e telele nako e telele kapa ea polokelo e tla fokotsa sekhahla sa meholo.
2.6 HydroxypropyL methylcelulose Antie e ka fana ka tšebetso e ka holimo, e bonts'ang litekanyetso tse lekaneng le tse sa feleng. E na le motho ea hlabang ka katleho tsamaisong ea likarolo tse peli mme e ka sebelisoa e le seliba se sebetsang le se sirelletsang se sirelelitsoeng.
2.7 hydroxypropyL methylcelulose ameng e na le thepa e ntle ea lifilimi, 'me ke thepa e ntle ea ho koahela litafole le lipilisi. Membrane e thehiloeng ke eona ha e na mebala ebile e le thata. Haeba Glycerol e eketsoa, seboli ba eona se ka eketsoa. Kamora kalafo ea bokaholimo, sehlahisoa se hasana metsing a batang, 'me sekhahla sa disshootion se ka laoloa ke ho fetola tikoloho ea ph. E sebelisoa litoropong tsa ho lokolla butle le litokisetso tsa litokisetso tsa tumellano.
3. Sesebelisoa sa sehlahisoa
3.1. E sebelisoa joalo ka moemeli ea khomarelang le o sa fetoheng
HPMC e sebelisetsoa ho khothaletsa ho felisoa hoa lithethefatsi le mokhoa oa lits'ebetso tsa ho lokolla Moemeli le litaba tse phahameng tsa sekhomaretsi bakeng sa glue, sebelisa feela ho kena ka mofuta o fapaneng le litlhoko tse fapaneng, kakaretso ke 2% ~ 5%.
HPMC e nang le bothata ba HPMC le mahloriso a itseng a Ethanol ho etsa binder e kopaneng; Mohlala: Tharollo ea mahlo a 3,5% hpmc tharollo ea tharollo ea 55% e ile ea sebelisetsoa ho qhekelloa ha li-capsules tse 38% ho fihlela HPMC.
HPMC e ka khangoa ke mekhabiso e nang le likarolo tse fapaneng le khatello e fapaneng ea starch ea Slurry kamora ho qhalana; Ho felisoa ha matlapa a erythromycin anic-Comated ho tloha 38.26% ho 97.38% ea 2% hpmc le 8% starch e kopantsoe.
2.2. Etsa hore filimi e koaletsoe ke lifilimi le filimi e thetsang
HPMC e le thepa e thata ea metsi ea metsi e na le litšobotsi tse latelang: Tharollo ea tharollo e leka-lekaneng; Ts'ebetso ea ho tšoarela e bonolo; Filimi e ntle ea ho theha thepa; E ka boloka sebopeho sa sekhelo, se ngotsoeng; E ka ba mongobo o sa keneleng; E ka 'mala, tatso ea khalemelo. Sehlahisoa sena se sebelisoa e le baesekele e qhibilihang ea metsi bakeng sa matlapa le lipilisi tse tlase, le ho koaheloa ke sekepe se sa boneng ka metsing, palo ea USAGE e 2% -5%.
2.3, joalo ka moemeli ea toikisang le phetoho e kholo ea ts'ireletso ea colloridal
HPMC e sebelisoang joalo ka moemeli ea thabiseng ke 0.45% ~ 1.0%, e ka sebelisoa e le marotholi a mahlo le moemeli oa methapo; E sebelisoa ho eketsa botsitso ba sekhobo sa Hydrophomcc, ho thibela mokoputsi oa mokokotlo, pula, litekanyetso tse tloaelehileng ke 0.5%.
2.4, joalo ka blocker, litefiso tse butle butle, moemeli oa tumello ea theko e laoloang
Moetsi oa lifoto tsa HPMC o sebelisetsoa ho lokisa li-blockers le baemeli ba rekisoang ba li-hatch tse kopaneng le hydrophilic Gel Skeleton e Kholisitsoeng. Mohlala o tlase oa litaba ke o hlohlelletsang oa ho lokolloa kapa ho lokolloa ka thata ka potlako, ho lateloe ke tokollo e atlehileng ea mali.
2.5. Gel le suppesitory matrix
Lisebelisoa tsa hydrogl le litokisetso tsa gastric li ka lokisoa ka ho sebelisa tšobotsi ea sebopeho sa hydrogel e sebelisoang hangata ke hpmc ka metsing.
2.6 Lisebelisoa tsa likokoana-hloko tse thusang
Metinelidazole e ne e tsoakiloe le HPMC le Polycarbolethylene 934 ho mochifi ea rekisoang ho etsa li-halika tse hatisitsoeng tse 250mg. Teko ea Vitro Dissoltion e bonts'a hore ho hlophisoa kapele ka metsi, 'me tokollo ea lithethefatsi e laoloa ke phapang ke litsi. Ts'ebetso ea phoofolo e bonts'a hore sistimi ea ho lokolla e ncha ea lithethefatsi e bile le thepa ea bohlokoa ea likokoana-hloko e eang ho Bovine Sublingual Mucosa e tlase.
2.7, joalo ka thuso ea ho emisoa
Sebopeho se phahameng sa sehlahisoa sena ke thuso e ntle ea ho emisoa bakeng sa litokisetso tsa metsi tsa metsi, litekanyetso tsa eona tse tloaelehileng ke 0.5% = 1.5%.
4. Mehlala ea kopo
4.1 Thahasello ea Filimi ea 4.1: hpmc 2kg, talc 2k 1kg, e 95% Ho na le mekhoa e 'meli ea ho e etsa.
4.1.1 Ho lokisa metsi a koahelang metsi a koahetsoeng ka har'a metsi: Kenya kakaretso ea HPMC ho 95% ho bona tharollo ea 'mele . Kopanya 80% ea tharollo (20% bakeng sa Polish) ka oli ea castor, ea lilemo li 12 80 le propylene.
4.1.2 Ho hlophisoa ha likolobe tse isehang (joalo ka tšepe) bo koahetsoeng ke metsi HPMC e kolobisitsoeng ka 95%, le metsi a pepesehileng ho etsa tharollo ea tšoaetso ea 2% HPMC. 20% ea tharollo ena e nkiloe bakeng sa phetolelo ea ho pola, 'me tharollo e setseng ea 80% e ne e lokisitsoe ke mokhoa o bolingoang, ebe likarolo tse ling li kenngoa le ho kopanya le eona. Ts'ebetso ea ho kenella ea mokelikeli oa leoatle: Tšela leqephe la lijo-thollo ka pitseng, ka mor'a ho potoloha, ho tla le fafatsa, ho chesa, ka mor'a ho fafatsa, tsoela pele ho omella Ka moea o chesang oa 5 ~ 10min e ka tsoa ka pitseng, e behe mohaleng hore e ome ho feta 8h.
4.24-Ipheeme ea mahlo 50μge 50μnit ea " Sehlahisoa sena se entsoe ka thepa ea lifilimi.
4.3 Makhotla a botona a botšehali (0.4g ± 0.08g) SMZ (80 Mesh), mokhoa oa ho lokisa Kopanya SMZ le TMP, ebe u eketsa starch le kopanya bakeng sa 5min. Ka tharollo ea 3% hpmc e telele Sehlahisoa sena se sebelisoa haholo e le sebali. Khetho ea matlapa a matlakala e ne e le 96% / 20min.
4.4 Matlapate ea Piperate (0.25G) Pipelira VIPERATE 80 Mesh 25kg, stirds (120 Mesh) 2.1kg ea magnesiune e lekanang. Mokhoa oa tlhahiso ea eona ke ho kopanya Pipeperic Acid, stanc, HPMC Feta matlapa. Ka starch e le moemeli oa ho hlakola, sekhahla sa disshoot sa tablet ha se ka tlase ho 80% / 2min, e phahame ho feta lihlahisoa tse tšoanang Japane.
4,5 Tear ea Maiketsetso ea HPMC-4000, HPMC-4000, HPMC-5000 Mokhoa oa eona oa tlhahiso ke HPMC e behiloeng ka metsing a 15ml, ho metsi a 35l, eketsa metsi a mangata, ebe u tsoakana le ka nako e lekaneng, e tsoa ho bosiu Ka bonolo, tšela filtritara Ha e sebelisoa ha e sebelisoa bakeng sa sethala sa ka tlung ea Chamberscopy, e ka eketsa tekanyetso ea sehlahisoa sena, 0,7% ~ 1.5% e loketse.
4.6 MeththorPhan e laoloang ke Meththorfan MeththorPhan Resin Say 187.0M, Lacto70.0Mg E hlophisitsoe e le matlakala ka mokhoa o tloaelehileng. Sehlahisoa sena se sebelisoa e le thepa e rekisoang.
4.7 bakeng sa li-pluts tsa avantomycin ⅳ mapolanka, 2149g avantomycin ⅳ motsoako oa metsi a 15% Grankhales ea omisitsoeng 575g le 62.5g hydroxxpropixpropikolese e-50 e ne e tsoakiloe hantle, ebe e beiloe masenke ka matlapeng ho fumana matlafatso e tsoelang pele ea Vangoard Mycin IN. Sehlahisoa sena se sebelisoa e le thepa e koaletsoeng butle butle.
4.8 Niffine e tsitsitseng - Granupine e tsitsitseng - likarolo tse 3 tsa hydropine, likarolo tse 3 tsa ENYLL. Mokhoa. Sekhahla sa lithethefatsi sa ho lokolloa ha li-granules ha lia ka tsa angoa ke phetoho ea ph mme e ne e tsamaea butle ho feta ea li-granules tse fumanehang khoebong. Kamora lihora tse 12 tsa tsamaiso ea molomo, ho tsepamisa mohopolo ho 12MG / ML, 'me ho ne ho se phapang ea motho ka mong.
4.9 apranthaol hydrochlor e tšehelitsoeng e tšehelitsoeng e kopantsoeng 60kg, microcrystaline clloulose 40kg, e eketsa metsi a 50 ho etsa li-granules. HPMC1KG le EC 9KG e ne e tsoakiloe ka har'a solvende e tsoakiloeng (methylene changide e tsoakiloeng Mm Screen Screen Screen, ebe u tletse ka mokopi oa lejoe ka mochini o ikhethang oa capsule. Sekepe se seng le se seng se na le 160MG ea 160mg ea propranolol hydrokelling spherical sparical.
4.10 Naprolol HCL Skeleton e lokiselitsoe ka ho kopanya Naprolol hcc: CCC-na karolong ea 1 :.25: 2.25. Sekhahla sa ho lokolla se ne se le haufi le taolo ea zero nakong ea lihora tse 12.
Lithethefatsi tse ling li ka boela tsa etsoa ka lisebelisoa tse kopaneng, tse kang METaprolol: HPMC: CMMC-NA HOBANE: 1.25; 1.25; 1.25; 1.25; 1.25; 1.25; 1.25; Allyllprolol: HPMC ho latela 1: 2.8: 2.92 karolelano ea 2.92. Sekhahla sa ho lokolla se ne se le haufi le taolo ea zero nakong ea lihora tse 12.
4.11 Skeleton Skeleton ea lisebelisoa tse tsoakiloeng tsa lisebelisoa tse tletseng tsa Ethylamine li ne li lokiselitsoe ka mokhoa o tloaelehileng o sebeliloeng ka mokhoa o tloaelehileng oa silica gel: cmc-na: hpmc 1 :.4. Sethethefatsi se ka lokolloa ka 12h ka bobeli vitro le vivo, 'me mokhoa oa ho lokolloa o mela o ne o e-na le tokollo e ntle. Liphetho tsa tlhahlobo ea botsitso e potlakileng ho latela melao ea FDA ho latela melao ea FDA ho paka hore bophelo ba polokelo ba sehlahisoa sena bo ka ba lilemo tse 2.
4.12 HPMC (50Fa p) (likarolo tse 50), HPMC (likarolo tse 60) Spray o omisitsoeng. Sehlahisoa sena se na le 80% ea moriana o ka sehloohong.
4.13 Theophylline hydrophilic gel skeleton Boloka mali a atlehang a malifatso ea 'mele oa motho bakeng sa 12h ka mor'a tsamaiso ea molomo.
Nako ea poso: Sep-20-2022