Hydroxyethylcellulose (HEC) ke polima e sa ionic, e qhibilihang ka metsing e tsoang ho selulose. Sebopeho sa eona se ikhethang sa lik'hemik'hale le thepa e etsa hore e be motsoako o sebetsang ka mefuta-futa oa lisebelisoa tse fapaneng ho pholletsa le liindasteri tse kang meriana, litlolo, lijo le tlhokomelo ea botho. E 'ngoe ea litšoaneleho tsa eona tse hlokomelehang ke thepa ea eona e ntle ea ho emisoa, e bapalang karolo ea bohlokoa mekhoeng e mengata.
Sebopeho le Thepa ea HEC
HEC e tsoa ho cellulose, e leng polima ea tlhaho e fumanehang maboteng a lisele tsa semela. Ka letoto la karabelo ea lik'hemik'hale, lihlopha tsa hydroxyethyl li hlahisoa mokokotlong oa cellulose, e leng se hlahisang polymer e qhibilihang ka metsi e nang le thepa e ikhethang.
Sebopeho sa Lik'hemik'hale: Sebopeho sa motheo sa selulose se na le likarolo tse pheta-phetoang tsa tsoekere tse hokahantsoeng ka libonto tsa β-1,4-glycosidic. Ho HEC, lihlopha tse ling tsa hydroxyl (-OH) li-unit tsa tsoekere li nkeloa sebaka ke lihlopha tsa hydroxyethyl (-OCH2CH2OH). Phapang ena e fana ka ho qhibiliha ha metsi ho polymer ha e ntse e boloka sebopeho sa mokokotlo oa selulose.
Ho qhibiliha ha Metsi: HEC e qhibiliha haholo ka metsing, e etsa litharollo tse hlakileng, tse hlakileng. The degree of substitution (DS), e bonts'ang palo e tloaelehileng ea lihlopha tsa hydroxyethyl ho yuniti ea tsoekere, e susumetsa ho qhibiliha ha polymer le lisebelisoa tse ling. Litekanyetso tse phahameng tsa DS hangata li fella ka ho qhibiliha ho hoholo ha metsi.
Viscosity: Litharollo tsa HEC li bonts'a boitšoaro ba pseudoplastic, ho bolelang hore viscosity ea bona e fokotseha tlas'a khatello ea ho kuta. Thepa ena e na le molemo lits'ebetsong tse kang liphahlo le li-adhesives, moo thepa e hlokang ho phalla habonolo nakong ea kopo empa e boloka viscosity ha e phomotse.
Tlhahiso ea Lifilimi: HEC e ka etsa lifilimi tse pepeneneng, tse tenyetsehang ha li omisitsoe, li etsa hore e be tse loketseng ho sebelisoa e le moemeli oa ho etsa lifilimi lits'ebetsong tse fapaneng.
Thepa ea ho emisoa ha HEC
Ho emisoa ho bolela bokhoni ba ntho e tiileng ea ho lula e hasane ka ho lekana ka har'a mokelikeli ntle le ho lula ha nako e ntse e ea. HEC e bonts'a thepa e ntle ea ho emisa ka lebaka la lintlha tse 'maloa:
Hydration le ho Ruruha: Ha likaroloana tsa HEC li qhalakanngoa ka har'a mokelikeli, li kolobisoa le ho ruruha, ho etsa marang-rang a mararo a tšoasang le ho emisa likaroloana tse tiileng. Sebopeho sa hydrophilic sa HEC se thusa ho kenngoa ha metsi, se lebisang ho eketseha ha viscosity le ho ntlafatsa botsitso ba ho emisa.
Phatlalatso ea Size ea Particle: HEC e ka khona ho emisa mefuta e mengata ea likaroloana ka katleho ka lebaka la bokhoni ba eona ba ho theha marang-rang a nang le mefuta e sa tšoaneng ea mesh. Tefo ena e etsa hore e loketse ho emisa likaroloana tse ntle le tse mahoashe mefuteng e fapaneng.
Boitšoaro ba Thixotropic: Litharollo tsa HEC li bonts'a boitšoaro ba thixotropic, ho bolelang hore viscosity ea bona e fokotseha ha nako e ntse e feta tlas'a khatello ea kamehla ea ho kuta 'me e hlaphoheloa ha khatello e tlosoa. Thepa ena e lumella ho tšela le ho sebelisoa habonolo ha ho ntse ho boloka botsitso le ho emisoa ha likaroloana tse tiileng.
pH botsitso: HEC e tsitsitse ho feta mefuta e mengata ea pH, e etsa hore e loketse ho sebelisoa ka metsoako ea acidic, neutral, le alkaline ntle le ho senya thepa ea eona ea ho emisa.
Likopo tsa HEC ho Suspension Formulations
Thepa e ntle ea ho emisoa ea HEC e e etsa motsoako oa bohlokoa lihlahisoa tse ngata ho liindasteri tse fapaneng:
Lipente le Liaparo: HEC e sebelisoa e le ntho e teteaneng le e emisang lipente le liphahlo tse entsoeng ka metsi ho thibela ho lokisa li-pigments le li-additives. Boitšoaro ba eona ba pseudoplastic bo thusa ts'ebeliso e bonolo le tšireletso e tšoanang.
Lihlahisoa tsa Tlhokomelo ea Botho: Ka li-shampoo, ho hlatsoa 'mele, le lihlahisoa tse ling tsa tlhokomelo ea botho, HEC e thusa ho emisa metsoako ea likaroloana tse kang li-exfoliants, li-pigments le lifaha tse nkhang hamonate, ho netefatsa hore esita le ho ajoa le botsitso ba sebopeho.
Litlhahiso tsa Meriana: HEC e sebelisoa ho emisoa ha meriana ho emisa metsoako e sebetsang le ho ntlafatsa tatso le botsitso ba mefuta ea litekanyetso tsa mokelikeli oa molomo. Ho lumellana ha eona le mefuta e mengata ea li-API (Active Pharmaceutical Ingredients) le li-excipients li etsa hore e be khetho e ratoang bakeng sa baetsi ba lihlahisoa.
Lihlahisoa tsa Lijo le Seno: HEC e sebelisoa lits'ebetsong tsa lijo tse kang liroso tsa salate, li-sauces le lino tse tahang ho emisa metsoako e sa qhibiliheng e kang litlama, linoko le makhasi. Sebopeho sa eona se se nang monko ebile se sa latsoeheng se etsa hore e be se loketseng ho sebelisoa mefuteng ea lijo ntle le ho ama litšobotsi tsa kutlo.
Hydroxyethylcellulose (HEC) ke polima e feto-fetohang e nang le thepa e ikhethang ea ho emisoa, e e etsa motsoako oa bohlokoa mefuteng e mengata e fapaneng ea liqapi ho pholletsa le liindasteri. Bokhoni ba eona ba ho emisa likaroloana tse tiileng ka ho lekana mecheng ea litaba tsa mokelikeli, hammoho le litšobotsi tse ling tse lakatsehang tse kang ho qhibiliha ha metsi, taolo ea viscosity, le botsitso ba pH, e etsa hore e be ea bohlokoa haholo ho baetsi ba lihlahisoa ba batlang ho fumana lihlahisoa tse tsitsitseng le tsa boleng bo holimo. Ha matsapa a lipatlisiso le nts'etsopele a ntse a tsoela pele, ts'ebeliso ea HEC mekhoeng ea ho emisoa e lebelletsoe ho hola ho ea pele, ho tsamaisa boqapi le ho ntlafatsa ts'ebetso ea lihlahisoa makaleng a fapaneng.
Nako ea poso: May-09-2024