HPMC e bitsoa hydroxypropyl methylcellulose.
Sehlahisoa sa HPMC se khetha selulose ea k'hothone e hloekileng haholo e le thepa e tala 'me e entsoe ka etherification e khethehileng tlas'a maemo a alkaline. Tshebetso eohle e phethoa tlas'a maemo a GMP le ho shebella ka mokhoa o itekanetseng, ntle le lisebelisoa tse sebetsang tse kang litho tsa liphoofolo le mafura.
Lintho tsa HPMC:
Sehlahisoa sa HPMC ke non-ionic cellulose ether, ponahalo ke phofo e tšoeu, e sa nkhang hamonate, e qhibiliha ka metsing le li-solvents tse ngata tsa polar (tse kang dichloroethane) le karolo e nepahetseng ea ethanol / metsi, propyl joala / metsi, joalo-joalo. mosebetsi, pepeneneng e phahameng le tshebetso e tsitsitseng. HPMC e na le thepa ea gel e futhumetseng, tharollo ea metsi a sehlahisoa e futhumatsoa ho theha pula ea li-gel, ebe e qhibiliha ka mor'a ho pholile, litlhaloso tse fapaneng tsa mocheso oa lihlahisoa tsa lihlahisoa li fapane. Solubility e fetoha le viscosity, ho theola viscosity, ho qhibiliha ho hoholo, litlhaloso tse fapaneng tsa HPMC li na le phapang e itseng ea thepa ea eona, HPMC ka metsing ha e amehe ke boleng ba PH. Boholo ba likaroloana: Sekhahla sa ho feta sa 100 mesh se seholo ho feta 100%. Boima ba bongata: 0.25-0.70g/ (hangata hoo e ka bang 0.5g/), matla a khoheli a itseng 1.26-1.31. Mocheso oa ho fetoha ha mebala: 190-200 ℃, mocheso oa carbonization: 280-300 ℃. Khatello ea sefahleho: 42-56dyn / cm ka tharollo ea 2% ea metsi. Ka ho eketseha ha methoxyl, ntlha ea gel e fokotsehile, ho qhibiliha ha metsi ho ile ha eketseha, 'me mosebetsi oa holim'a metsi le oona oa eketseha. HPMC e na le litšoaneleho tsa ho tenya, ho letsoai, ho ba le molora o tlase, botsitso ba PH, ho boloka metsi, botsitso ba dimensional, ho etsa filimi e babatsehang le khanyetso e pharaletseng ea enzyme, ho arohana le ho kopana.
Lisebelisoa tsa HPMC:
1. Letlapa la ho roala: HPMC e sebelisoang e le thepa ea ho roala filimi ka ho itokisa ka thata, e ka theha filimi e thata, e boreleli le e ntle, tšebeliso ea mahloriso ea 2% -8%. Ka mor'a ho roala, botsitso ba moemeli ho khanya, mocheso le mongobo o eketseha; Ha e na tatso ebile ha e na monko, ho bonolo ho e nka, le HPMC pigment, sunscreen, lubricant le tse ling tse tsamaellanang hantle tsa thepa. Ho roala ho tloaelehileng: metsi kapa 30-80% ethanol ho qhala HPMC, ka tharollo ea 3-6%, ho eketsa lisebelisoa tse thusang (tse kang: mocheso oa mobu -80, oli ea castor, PEG400, talc, joalo-joalo).
2. Lera la ho itšehla thajana le qhibilihang ka hare: holim'a matlapa le li-granules, ho roala ha HPMC ho sebelisoa ka lekhetlo la pele e le lera le ka tlaase la ho itšehla thajana, ebe le koahetsoe ka lera la thepa e qhibilihang ke enteric ea HPMCP. Filimi ea HPMC e ka ntlafatsa botsitso ba sesebelisoa sa ho qhibiliha sa enteric polokelong.
3. Tokisetso e tsitsitseng ea ho lokolloa: ho sebelisa HPMC e le moemeli oa pore-inducing le ho itšetleha ka ethyl cellulose e le lisebelisoa tsa skeleton, matlapa a nako e telele a ka etsoang ka nako e telele a ka etsoa.
4. Thickening moemeli le colloid sireletsang sekgomaretsi le mahlo a marotholi: HPMC bakeng sa thickening moemeli ka tloaelo sebelisoa mahloriso ea 0.45-1%.
5. Sekhomaretsi: HPMC e le sekhomaretsi se akaretsang sa 2% -5%, se sebelisetsoang ho ntlafatsa botsitso ba sekhomaretsi sa hydrophobic, mahloriso a tloaelehileng a 0.5-1.5%.
6. Moemeli oa ho lieha, moemeli oa tokollo o laoloang le moemeli oa ho emisa. Moemeli oa ho emisa: tekanyo e tloaelehileng ea moemeli oa ho emisa ke 0.5-1.5%.
7. Lijo: HPMC e le thickening moemeli a phaella ka ho mefuta e fapaneng ya dino, lihlahisoa tsa lebese, li-condiments, lijo tse nang le phepo e nepahetseng, e le mohatelli, binder, emulsifier, moemeli oa ho emisa, stabilizer, moemeli oa ho boloka metsi, excifer, joalo-joalo.
8. E sebelisoa ka litlolo e le li-adhesives, emulsifiers, li-agent tsa ho etsa lifilimi, joalo-joalo.
Nako ea poso: Jan-14-2022