Ho qhala Hydroxypropyl Methylcellulose (HPMC) ka metsing ke mokhoa o tloaelehileng liindastering tse fapa-fapaneng, ho akarelletsa le meriana, lijo, litlolo le kaho. HPMC ke motsoako oa selulose o etsang tharollo e hlakileng, e se nang 'mala, le ea viscous ha e kopantsoe le metsi. Tharollo ena e bonts'a thepa e ikhethang joalo ka ho tenya, ho tlama, ho etsa lifilimi, le ho boloka ho lokolloa ha metsoako e sebetsang. Ts'ebetso ea ho qhala ha HPMC ka metsing e kenyelletsa mehato e ikhethileng ho netefatsa phallo e nepahetseng le ho tšoana.
Selelekela ho HPMC:
Hydroxypropyl Methylcellulose (HPMC) ke ether e seng ionic cellulose e nkiloeng ho selulose ea tlhaho ea polymer. E entsoe ka ho phekola cellulose ka propylene oxide le methyl chloride. HPMC e sebelisoa haholo liindastering tse sa tšoaneng ka lebaka la thepa ea eona e babatsehang ea ho etsa lifilimi, e teteaneng, e tsitsitseng le ea ho boloka metsi. Lisebelisoa tsa mantlha tsa HPMC li kenyelletsa:
Meriana ea Meriana: E sebelisoa e le setlamo, sa pele sa filimi, se feto-fetohang sa viscosity, le moemeli oa tokollo e laoloang matlapeng, li-capsules, litlolo, le li-suspension.
Indasteri ea Lijo: E sebelisoa e le setei, se tsitsitseng, emulsifier, le se bolokang mongobo lihlahisoa tsa lijo tse kang li-sauces, lebese le thepa e halikiloeng.
Kaho: E sebetsa e le ntho ea ho boloka metsi, sekhomaretsi le seteifatsi linthong tse entsoeng ka samente, lipolasetere tse entsoeng ka gypsum le likhomaretsi tsa lithaele.
Litlolo: E sebetsa e le setei, sa pele sa filimi, le emulsion stabilizer linthong tsa litlolo, litlolo, li-shampoo le lihlahisoa tsa tlhokomelo ea motho.
Tshebetso ea ho qhala ea HPMC ka Metsing:
Ho qhala HPMC ka metsing ho kenyelletsa mehato e 'maloa ea bohlokoa ho fihlela tharollo e ts'oanang le e tsitsitseng:
Khetho ea Kereiti ea HPMC: Khetha kereiti e nepahetseng ea HPMC ho ipapisitsoe le viscosity e lakatsehang, boholo ba likaroloana, le boemo ba ho e nkela sebaka. Limaraka tse fapaneng li fana ka likhato tse fapaneng tsa viscosity le litšobotsi tsa ho qhibiliha.
Tokisetso ea Metsi: Sebelisa metsi a hloekisitsoeng kapa a hloekisitsoeng ho lokisa tharollo. Boleng ba metsi bo ka ama haholo ts'ebetso ea ho qhibiliha le thepa ea tharollo ea ho qetela. Qoba ho sebelisa metsi a thata kapa metsi a nang le litšila tse ka sitisang ho qhibiliha.
Bekha le Methatso: Lekanya ka nepo palo e hlokahalang ea HPMC u sebelisa tekanyo ea dijithale. Tekanyo e khothaletsoang ea HPMC metsing e fapana ho latela ts'ebeliso e reriloeng. Ka kakaretso, likhakanyo tse tlohang ho 0.1% ho isa ho 5% w/w li tloaelehile lits'ebetsong tse ngata.
Mothati oa Hydration: Fafatsa HPMC e lekantsoeng butle le ka ho lekana holim'a metsi ha u ntse u sisinyeha u sa khaotse. Qoba ho eketsa HPMC ka clumps tse kholo ho thibela sebopeho sa likotola kapa agglomerate. Lumella HPMC ho fa metsi le ho hasana butle-butle ka metsing.
Ho kopanya le ho Agitation: Sebelisa thepa e loketseng ea ho kopanya e kang magnetic stirrer, propeller mixer, kapa high-shear mixer ho thusa ho hasana ha likaroloana tsa HPMC metsing. Boloka pherekano e bonolo ho thibela ho phophoma ho feteletseng kapa ho koaleha moea.
Taolo ea Mocheso: Sheba le ho laola mocheso nakong ea ts'ebetso ea ho qhibiliha. Maemong a mangata, mocheso oa kamore (20-25 ° C) o lekane ho qhala HPMC. Leha ho le joalo, bakeng sa ho qhibiliha ka potlako kapa metsoako e itseng, ho ka 'na ha hlokahala mocheso o phahameng. Qoba ho chesa haholo, kaha ho ka senya polymer le ho ama thepa ea tharollo.
Nako ea ho Qhala: Ho felisoa ka botlalo ha HPMC ho ka nka lihora tse 'maloa, ho ipapisitse le kereiti, boholo ba karoloana, le matla a pherekano. Tsoela pele ho hlohlelletsa ho fihlela tharollo e hlaka, e pepenene, 'me e se na likaroloana tse bonahalang kapa li-agglomerate.
Phetoho ea pH (haeba ho hlokahala): Litlhophisong tse ling, phetoho ea pH e ka hlokahala ho ntlafatsa botsitso le ts'ebetso ea tharollo ea HPMC. Sebelisa li-buffering agents tse loketseng kapa u lokise pH u sebelisa li-acids kapa bases ho latela litlhoko tse khethehileng.
Filtration (haeba ho hlokeha): Ka mor'a ho qhibiliha ka ho feletseng, sefa tharollo ea HPMC ka sesefo se setle sa letlooeng kapa pampiri ea sefa ho tlosa likaroloana leha e le life tse sa qhibilihang kapa litšila. Mohato ona o tiisa ho hlaka le homogeneity ea tharollo.
Polokelo le Botsitso: Boloka tharollo ea HPMC e lokisitsoeng ka har'a lijana tse hloekileng, tse sa keneng moea hole le letsatsi le mocheso o feteletseng. Litharollo tse bolokiloeng hantle li lula li tsitsitse ka nako e telele ntle le liphetoho tse kholo tsa viscosity kapa thepa e 'ngoe.
Lintlha tse Amang Pheliso ea HPMC:
Lintlha tse 'maloa li ka susumetsa ts'ebetso ea ho qhala le thepa ea tharollo ea HPMC:
Boholo ba Karolo le Kereiti: Limaraka tse phofshoana tsa HPMC li qhibiliha habonolo ho feta likaroloana tse mahoashe ka lebaka la ho eketseha ha sebaka le kinetics ea hydration e potlakileng.
Mocheso: Lithempereichara tse phahameng li potlakisa sekhahla sa ho qhibiliha ha HPMC empa hape li ka lebisa ho tahlehelo ea viscosity kapa ho senyeha ha maemo a feteletseng.
Lebelo la Agitation: Ho ferekana ho nepahetseng ho tiisa ho hasana ho tšoanang ha likaroloana tsa HPMC le ho khothalletsa ho qhibiliha ka potlako. Ho ferekana ho feteletseng ho ka hlahisa lipululana tsa moea kapa foam ka har'a tharollo.
Boleng ba Metsi: Boleng ba metsi a sebelisoang bakeng sa ho qhibiliha bo ama ho hlaka, botsitso le ponahalo ea tharollo ea HPMC. Metsi a hloekisitsoeng kapa a hloekisitsoeng a khethoa ho fokotsa litšila le li-ion tse ka sitisang ho qhibiliha.
pH: The pH ea tharollo e ka susumetsa ho solubility le botsitso ba HPMC. Ho fetola pH ka har'a sebaka se nepahetseng bakeng sa kereiti e ikhethileng ea HPMC ho ka ntlafatsa phallo le ts'ebetso.
Matla a Ionic: Matsoai a mangata kapa li-ion tharollong a ka kena-kenana le ho qhibiliha ha HPMC kapa a baka ho ruruha. Sebelisa metsi a sa hloekang kapa u fetole motsoako oa letsoai ha ho hlokahala.
Mabotho a Shear: Maemo a phahameng a ho kuta kapa a ho sebetsa a ka ama thepa ea rheological le ts'ebetso ea tharollo ea HPMC, haholo lits'ebetsong tsa indasteri.
Malebela a ho rarolla mathata:
Haeba u kopana le mathata a ho qhaqha HPMC kapa u na le mathata ka boleng ba tharollo, nahana ka malebela a latelang a ho rarolla mathata:
Eketsa Moferefere: Ntlafatsa matla a ho kopanya kapa sebelisa lisebelisoa tse khethehileng tsa ho kopanya ho khothaletsa phallo e ntle le ho qhibiliha ha likaroloana tsa HPMC.
Fetola Mocheso: Ntlafatsa maemo a mocheso ka har'a sebaka se khothalelitsoeng ho thusa ho qhibiliha ka potlako ntle le ho senya botsitso ba polymer.
Phokotso ea Boholo ba Karolo: Sebelisa limaraka tse holimo tsa HPMC kapa sebelisa mekhoa ea ho fokotsa boholo joalo ka ho sila kapa micronization ho ntlafatsa kinetics ea ho qhibiliha.
Phetoho ea pH: Lekola pH ea tharollo 'me u lokise ha ho hlokahala ho boloka maemo a nepahetseng bakeng sa ho qhibiliha le botsitso ba HPMC.
Boleng ba Metsi: Netefatsa bohloeki le boleng ba metsi a sebelisetsoang ho qhibiliha ka ho sebelisa mekhoa e loketseng ea ho hloekisa kapa ea ho hloekisa.
Teko ea Tumellano: Etsa lithuto tsa tšebelisano le metsoako e meng ea sebopeho ho tseba tšebelisano efe kapa efe kapa ho se lumellane ho ka amang ho qhalana.
Buisana le Litaelo tsa Baetsi: Sheba likhothaletso le litataiso tsa moetsi bakeng sa limaraka tse ikhethileng tsa HPMC mabapi le maemo a ho qhalana, mekhahlelo ea mahloriso, le likeletso tsa tharollo ea mathata.
Ho qhala Hydroxypropyl Methylcellulose (HPMC) ka metsing ke mohato oa bohlokoa lits'ebetsong tse fapaneng tsa indasteri, ho kenyeletsoa meriana, lijo, kaho le litlolo. Ka ho latela mekhoa e khothaletsoang le ho nahana ka lintlha tse ka sehloohong tse kang boholo ba likaroloana, mocheso, ho ferekana, le boleng ba metsi, u ka finyella tharollo ea HPMC e ts'oanang le e tsitsitseng ka thepa ea rheological e lakatsehang. Ho feta moo, mekhoa ea ho rarolla mathata le maano a ho ntlafatsa li ka thusa ho hlola liphephetso le ho netefatsa ho felisoa ka katleho ha HPMC bakeng sa lits'ebetso tse fapaneng. Ho utloisisa mokhoa oa ho qhala le eona
Nako ea poso: Mar-09-2024