Ho qhekella hydroxypropyl methylcelulose (HPMC) ka har'a indasteri e tloaelehileng, ho kenyelletsa merafo, lijo, litlolo le kaho. HPMC ke sesebelisoa se matla se etsang pepere, se se nang mebala, le ho hlahlojoa le lefu la viscous ha li tsoatswa le metsi. Tharollo ena e bonts'a thepa e ikhethang joaloka thipa, e tlamang, e etsa filimi e thehang lifiliming, le ho lokolloa ha metsoako e sebetsang. Mokhoa oa ho qhalana ha HPMC ka metsing o kenyelletsa mehato e itseng ho netefatsa ho pepapele hantle le ntho e ts'oanang.
Kenyelletso ea HPMC:
Hydroxypropypropinyl methylcellll (HPMC) ke selefounu e seng ea Ionic ether e tsoang cellulose ea tlhaho. E kenya letsoho ka ho phekola Celsulose le Oxide Oxide le Methyl chloride. HPMC e sebelisoa haholo indastering ea eona e fapaneng ka lebaka la ho theha filimi ea eona e ntlehali ea filimi e ntle, e matlafatsang, ho tsitsipana le thepa ea ho boloka metsi. Likopo tsa mantlha tsa HPMC li kenyeletsa:
Pharmacticalical: E sebelisoa e le mojaro, Movie
Indasteri ea lijo:
Kaho: Ba sebetsa e le moemeli oa ho boloka metsi, khomarela le thickener lisebelisoa tse thehiloeng ho saense, le lidolara tsa gypps.
Li-cosmetics: Mesebetsi e le oahckener, oa pele oa filimi le emulsion le maemo a maholohali ka ho hopola, litlolo, shampoos le lihlahisoa tsa tlhokomelo.
Mokhoa oa ho qhalana oa HPMC ka metsing:
Ho qhala HPMC ka metsing ho kenyelletsa mehato e mengata ea bohlokoa ho fihlela tharollo e tšoanang le e tsitsitseng:
Khetho ea sehlopha sa HPMC: Khetha sehlopha se loketseng HPMC ho ipapisitse le pono e lakatsehang, boholo ba karoloana le boemo ba ho nka karolo. Maqephe a fapaneng a fana ka likhato tse fapaneng tsa sebopeho sa pono le litsi tsa tharollo.
Ho hlophisoa ha metsi: Sebelisa metsi a hloekisitsoeng kapa a behiloeng kotsing ea ho lokisa tharollo. Boleng ba metsi bo ka ama mokhoa oa ho felisoa ka bongata le thepa ea tharollo ea ho qetela. Qoba ho sebelisa metsi a thata kapa metsi a nang le liphoso tse ka u sitisang ho khefuleha.
Ho lekanya le ho lekanya: ho rarolla palo e hlokahalang ea HPMC e sebelisang botsitso ba dijithale. Khohlano e khothalelitsoeng ea HPMC ka metsing a fapana ho latela kopo e reriloeng. Ka kakaretso, khatello ea maikutlo e tlohang ho tloha ho 0,1% ho 5% w / w e tloaelehile bakeng sa lits'ebetso tse ngata.
Mokhahlelo oa Hyduration: Fafatsa HPMC e lekantsoeng butle le ka mokhoa o tsitsitseng ka holim'a metsi ha a ntse a tsitsipanya ka nako e tsoelang pele. Qoba ho eketsa HPMC ka li-cramps tse kholo ho thibela sebopeho sa litlolo kapa agglomerate. Lumella HPMC ho hydrate le ho lahla butle-butle metsing.
Ho kopanya le ho ferekanya: Sebelisa lisebelisoa tse loketseng tsa ho kopanya hammoho e le moqapi oa motlakase, moqapi oa makenete, kapa mongoli oa matla oa ho nolofatsa ho se hloella jpmc ka metsing. Boloka ho ferekana bonolo ho thibela ho holofala ho feteletseng kapa ho kopanngoa.
Taolo ea mocheso: hlokomela le ho laola mocheso nakong ea ho qhalana. Maemong a mangata, mocheso oa kamore (mocheso oa sebaka (20-25 ° C) o lekane ho qhala HpMC. Leha ho le joalo, bakeng sa discolotion e potlakileng kapa e tobileng, lithemparetjha tse phahameng li ka hlokahala. Qoba ho timetsa polyiting le ho ama thepa ea tharollo ea tharollo.
Nako ea ho felisoa: Ho felisoa ka ho felletseng ha HPMC ho ka nka lihora tse 'maloa, ho latela sehlopha, boholo ba karohano le matla a tšohanyetso. Tsoela pele ho hlohlelletsa ho fihlela tharollo e hlakile, pepeneneng, 'me e lokolohile ho likaroloana tse bonahalang kapa agglomerate.
Phetoho ea PH (haeba ho hlokahala): Ka liforomo tse ling, phetoho ea PH e kanna ea hlokahala ho ntlafatsa tharollo le tharollo ea tharollo ea HPMC. Sebelisa li-agents tse loketseng tsa buffer kapa ho lokisa pH li sebelisa li-acid kapa li-esses tse mabapi le litlhokahalo tse itseng.
Phetoho (haeba e hlokahala) Mohato ona o tiisa ho hlaka le homogeneity ea tharollo.
Ho boloka le ho tsitsa: Boloka tharollo e lokiselitsoeng ea HPMC ka lisepa tse hloekileng, airtic hole le khanya ea letsatsi le lithempa tsa motlakase. Litharollo tse bolokiloeng hantle li lula li tsitsitse nakong ea nako e telele ntle le liphetoho tsa bohlokoa ho viscosity kapa thepa e 'ngoe.
Lintlha tse amang phetisetso ea HPMC:
Ho na le lintlha tse 'maloa tse ka amang ts'ebetso ea dissullotion le thepa ea tharollo ea HPMC:
Boholo ba tsona le sehlopha
Mocheso: Boithuto bo phahameng bo potlakisa sekhahla sa disfonot sa HPMC empa hape ba ka lebisa ho tahlehelo ea pono kapa ho senyeha maemong a feteletseng.
Lebelo la Khalema: Thupelo e Loketseng e netefatsa ho se hloeha joalo ka likaroloana tsa HPMC le ho khothalletsa ho felisoa ka potlako. Ho tšeha ho feteletseng ho ka hlahisa bubble kapa foam ka tharollo.
Boleng ba metsi: Boleng ba metsi bo sebelisitsoeng bakeng sa khefu bo amang kelello, botsitso le pono ea tharollo ea HPMC. Metsi a hloekisitsoeng kapa a se a phelisitsoeng a khethoa ho fokotsa litšila le lihlekehleke tse ka sitisang ho khefuleha.
PH: PH ea tharollo e ka susumetsa ealloubility le botsitso ba HPMC. Ho fetola PH Ekong ea boholo bo nepahetseng bakeng sa sehlopha se ikhethileng sa HPMC ho ka ntlafatsa ho felisoa le ts'ebetso.
Matla a Ionic: Metsi a phahameng a letsoai kapa a ka tharollo a ka kena-kenana le litheolelo tsa HPMC kapa ho etsa hore ho itšehla thajana. Sebelisa metsi a utloisang bohloko kapa a fetohe ho tsepamisa letsoai ha ho hlokahala.
Lithatho tsa Shealand: Ho kopanya ho hoholo kapa ho sebetsa maemong a phahameng ho ka ama thepa ea phepelo le ts'ebetso ea tharollo ea HPMC, haholo-holo litsing tsa indasteri.
Malebela a ho rarolla mathata:
Haeba u tobana le mathata a ho qhala HpMC kapa ho fumana litaba tsa boleng ka boleng ba tharollo, nahana ka malebela a latelang a ho rarolla mathata.
Ho eketseha ha kobo: Ho ntlafatsa botebo ba ho kopanya kapa ho kopanya lisebelisoa tse ikhethang ho khothaletsa ho hasana le likabelo tsa HPMC.
Fetola mocheso: ntlafatsa maemo a mocheso ka har'a mofuta o khothalelitsoeng ho nolofatsa ho felisoa ka potlako u sa tsilatsila ho tsitsipana le polymer.
Phokotso ea boholo ba eona ea maemo
Phetoho ea PH: Lekola PH ea tharollo 'me u fetole moo ho hlokahalang ho boloka maemo a nepahetseng bakeng sa hpmc slubility le botsitso.
Boleng ba metsi: Ho netefatsa bohloeki le boleng ba metsi bo sebelisitsoeng ho khefutsa ka ho sebelisa mekhoa e loketseng ea ho fetoha.
Ho hlahloba ha ho etsa qeto: Ho etsa lithuto tse tsamaellanang le lisebelisoa tse ling ho khetholla litšebelisano kapa boikarabello bo ka amang ho felisoa.
Kopanya litataiso tsa moetsi: Sheba likeletso tsa moetsi le litataiso tsa limaraka tsa HPMC mabapi le ho qhalana le maemo a mahloriso le likeletso tsa mahloriso le likeletso.
Ho qhekella hydroxypropyl methylcelulose (HPMC) ka metsing ke mohato oa bohlokoa lits'ebetsong tse fapaneng tsa indasteri, lijo le litlolo. Ka ho latela lits'ebetso tse khothalelitsoeng le ho nahana ka lintlha tsa bohlokoa tse kang karohano, mocheso le boleng ba metsi. Ho feta moo, mekhoa ea ho rarolla maano le maano a ntlafatsang a ka thusa ho hlola mathata le ho netefatsa ho felisoa ha HPMC bakeng sa lits'ebetso tse fapaneng. Ho utloisisa ts'ebetso ea dissurete le eona
Nako ea poso: Mar-09-2024