Ho lokisa tharollo ea ho roala Hydroxypropyl Methylcellulose (HPMC) ke ts'ebetso ea mantlha indastering ea meriana le ea lijo. HPMC ke polymer e sebelisoang hangata ha ho etsoa litlolo ka lebaka la thepa ea eona e ntle ea ho etsa lifilimi, botsitso, le ho lumellana le metsoako e fapaneng e sebetsang. Litharollo tsa ho roala li sebelisoa ho fana ka likarolo tsa ts'ireletso, ho laola lifaele tsa tokollo, le ho ntlafatsa ponahalo le ts'ebetso ea matlapa, li-capsules le mefuta e meng e tiileng ea litekanyetso.
1. Lintho Tse Hlokehang:
Hydroxypropyl Methylcellulose (HPMC)
Solvent (hangata metsi kapa motsoako oa metsi le joala)
Plasticizer (ho ikhethela, ho ntlafatsa ho feto-fetoha ha filimi)
Li-additives tse ling (ho ikhethela, joalo ka li-colorants, opacifiers, kapa li-anti-tacking agents)
2. Thepa e Hlokahalang:
Sejana se kopanyang kapa setshelo
Stirrer (mochini kapa makenete)
Boima bo lekanyang
Mohloli oa ho futhumatsa (haeba ho hlokahala)
Sieve (haeba ho hlokahala ho tlosa maqeba)
pH meter (haeba ho hlokahala phetoho ea pH)
Lisebelisoa tsa polokeho (liatlana, likhalase, seaparo sa lab)
3. Mokhoa:
Mohato oa 1: Ho lekanya Metsoako
Lekanya palo e hlokahalang ea HPMC u sebelisa tekanyo ea bekha. Chelete e ka fapana ho latela mohopolo o lakatsehang oa tharollo ea ho roala le boholo ba batch.
Haeba u sebelisa polasetiki kapa li-additives tse ling, lekanya palo e hlokahalang.
Mohato oa 2: Ho Lokisetsa Solvent
Etsa qeto ea mofuta oa solvent e tla sebelisoa ho latela kopo le ho lumellana le metsoako e sebetsang.
Haeba o sebelisa metsi e le solvent, etsa bonnete ba hore a hloekile haholo 'me ka ho khetheha a hloekisitsoe kapa a hloekisitsoe.
Haeba u sebelisa motsoako oa metsi le joala, fumana tekanyo e nepahetseng e thehiloeng ho solubility ea HPMC le litšobotsi tse lakatsehang tsa tharollo ea ho roala.
Mohato oa 3: Ho kopanya
Beha sejana sa ho kopanya holim'a sekontiri ebe u eketsa mokelikeli.
Qala ho susumetsa solvent ka lebelo le itekanetseng.
Butle-butle eketsa phofo ea HPMC e lekantsoeng pele ka har'a motsoako o susumetsang ho qoba ho phunya.
Tsoela pele ho susumetsa ho fihlela phofo ea HPMC e qhalakanngoa ka mokhoa o ts'oanang ka har'a solvent. Ts'ebetso ena e kanna ea nka nako, ho ipapisitse le khatello ea HPMC le katleho ea lisebelisoa tse susumetsang.
Mohato oa 4: Ho futhumatsa (haeba ho hlokahala)
Haeba HPMC e sa qhibilihe ka ho feletseng mochesong oa kamore, ho ka hlokahala hore ho futhumale ha bonolo.
Chesa motsoako ha u ntse u susumetsa ho fihlela HPMC e qhibiliha ka ho feletseng. E-ba hlokolosi hore u se ke ua chesa haholo, kaha mocheso o feteletseng o ka senya HPMC kapa likarolo tse ling tsa tharollo.
Mohato oa 5: Keketso ea Plasticizer le Li-additives tse ling (haeba ho hlokahala)
Haeba u sebelisa plasticizer, e kenye ka tharollo butle-butle ha u ntse u hlohlelletsa.
Ka mokhoa o ts'oanang, eketsa li-additives tse ling tse lakatsehang joalo ka li-colorants kapa opacifiers mothating ona.
Mohato oa 6: Phetoho ea pH (haeba ho hlokahala)
Sheba pH ea tharollo ea ho roala ka pH meter.
Haeba pH e le ka ntle ho sebaka se lakatsehang bakeng sa botsitso kapa mabaka a tšebelisano, e fetole ka ho eketsa litharollo tse nyane tsa asiti kapa tsa mantlha ho latela.
Hlohlelletsa tharollo ka botlalo ka mor'a ho eketsoa ka 'ngoe 'me u hlahlobe hape pH ho fihlela boemo bo lakatsehang bo finyelloa.
Mohato oa 7: Ho Qetela Ho Kopanya le Tlhahlobo
Hang ha likarolo tsohle li kenyelletsoa 'me li kopane ka ho feletseng, tsoela pele ho susumetsa ka metsotso e seng mekae ho netefatsa homogeneity.
Etsa liteko life kapa life tse hlokahalang tsa boleng joalo ka tekanyo ea viscosity kapa tlhahlobo ea pono bakeng sa matšoao leha e le afe a likaroloana kapa karohano ea karolo.
Haeba ho hlokahala, fetisa tharollo ka sefe ho tlosa makukuno leha e le afe a setseng kapa likaroloana tse sa qhibilihang.
Mohato oa 8: Ho boloka le ho paka
Fetisetsa tharollo ea ho roala ea HPMC e lokisitsoeng ka har'a lijana tse loketseng tsa polokelo, haholo-holo libotlolo tsa khalase ea 'mala o mosehla kapa lijana tsa polasetiki tsa boleng bo holimo.
Ngola lijana ka tlhaiso-leseling e hlokahalang joalo ka nomoro ea batch, letsatsi la tokiso, mahloriso le maemo a polokelo.
Boloka tharollo sebakeng se phodileng, se omeletseng se sireleditsweng kganya le mongobo ho boloka botsitso le tjhelete ya bophelo.
4. Malebela le Mehopolo:
Kamehla latela mekhoa e metle ea laboratori le litataiso tsa polokeho ha u sebetsana le lik'hemik'hale le lisebelisoa.
Boloka bohloeki le sterility nakong eohle ea ho lokisa ho qoba tšoaetso.
Lekola ho lumellana ha tharollo ea ho roala le substrate e reriloeng (matlapa, li-capsules) pele ho ts'ebeliso e kholo.
Etsa lithuto tsa botsitso ho hlahloba ts'ebetso ea nako e telele le maemo a polokelo ea tharollo ea ho roala.
Ngola mokhoa oa ho lokisa le ho boloka lirekoto molemong oa taolo ea boleng le ho latela melao.
Nako ea poso: Mar-07-2024