Ho lokisa hydroxypropypropyproppyl methylcelllulose (HPMC) tharollo ea ho hohela ke ea bohlokoa ho indasteri ea pharmaconetic le ea lijo. HPMC ke sesebelisoa se tloaelehileng ka har'a foromo ea koae ka lebaka la ho etsa thepa e ntle ea filimi, botsitso le ho lumellana le metsoako e fapaneng. Litharollo tsa ho kopana li sebelisoa ho fana ka likarolo tsa tšireletso, liphika tsa ho lokolla lipapatso le sebopeho sa matlakala, li-capsules le lifoto tse thata tsa dosage.
1. Lisebelisoa tse hlokahalang:
HydroxypropypropyLese (HPMC)
Solvent (ka tloaelo metsi kapa motsoako oa metsi le joala)
Polasetiki (ea boikhethelo, ho ntlafatsa maemo a filimi)
Likhalase tse ling
2. Lisebelisoa lia hlokahala:
Sekepe se kopanyang kapa sejana
Mohlare (mochini kapa makenete)
Ho leka-lekana ho lekanya
Mohloli o futhumatsang (haeba ho hlokahala)
Sive (haeba ho hlokahala ho tlosa limps)
PH Mete
Sebaka sa polokeho (liatlana, Goggles, litlolo tsa lab)
3. Ts'ebetso:
Mohato oa 1: E lekola metsoako
Lekanya palo e hlokahalang ea HPMC e sebelisa teka-tekano e lekanyang. Chelete e kanna ea fapana ho latela khatello ea maikutlo e lakatsehang le boholo ba sehlopha.
Haeba u sebelisa mehala e meng ea polasetiki kapa litlatsetso tse ling, lekanya likarolo tse hlokahalang.
Mohato oa Bobeli: Ho hlophisoa ha solvent
Fumana mofuta oa solvent ho sebelisoa ho latela kopo le ho hokahana le metsoako e sebetsang.
Haeba e sebelisa metsi joalo ka ea solvent, netefatsa hore e hloekile e phahameng ebile e entsoe ka mokhoa o ikhethileng
Haeba u sebelisa motsoako oa metsi le joala, ho khetholla karolelano ea metsi a ipapisitseng le liliba tsa HPMC le litšobotsi tse lakatsehang tsa tharollo ea ho lema.
Mohato oa 3: Ho kopanya
Beha sejana se kopanyang sethaleng le ho eketsa boima.
Qala ho hlohlelletsa solvent ka lebelo le leka-lekaneng.
Butle-butle eketsa phofo ea HPMC e nang le boloi ea HPMC ho solvent e hlohlelletsa ho qoba ho khopatsa.
Tsoela pele ho hlohlelletsa ho fihlela ho phofo ea HPMC e hahuoa ka mokhoa o tšoanang ka ho fetesisa. Ts'ebetso ena e ka nka nako, ho latela khatello ea HPMC le katleho ea lisebelisoa tse hlasimollang.
Mohato oa 4: Ho futhumatsa (haeba ho hlokahala)
Haeba HPMC e sa qhibilihe ka mocheso o ka kamoreng, ho futhumatsa ka bonolo ho ka hlokahala.
Fafatsa motsoako ha u ntse u hlohlelletsa ho fihlela HPMC e felisitsoe ka botlalo. E-ba ea hlokolosi hore e se ke ea cheseha, kaha mocheso o feteletseng o ka nyenyefatsa HPMC kapa likarolo tse ling tsa tharollo.
Mohato oa 5: TLHALOSO EA PALOSTIZER le litlatsetso tse ling (haeba ho hlokahala)
Haeba u sebelisa mokhelo, ho eketsa tharollo butle-butle ha u ntse u susumelletsa.
Ka mokhoa o ts'oanang, eketsa litlatsetso tse ling tse lakatsehang tse kang li-colorator kapa li-opecilifera selemong sena.
Mohato oa 6: PH phetoho (haeba ho hlokahala)
Lekola pH ea tharollo ea ho lating u sebelisa ph mitater.
Haeba pH e felile ka tsela e lakatsehang bakeng sa mabaka a botsitso kapa mabaka, e fetohele ka ho eketsa tharollo ea acidic kapa ea mantlha.
Hlohlelletsa tharollo ka botlalo kamora ho kenyelletsa ph ho fihlela boemo bo lakatsehang bo fihlella.
Mohato oa 7: Ho Kopanya ho Pheta le Tlhahlobo
Hang ha likarolo tsohle li eketsoa ebile li tsoakane, tsoela pele ho hlohlelletsa metsotso e seng mekae ho netefatsa homogeneity.
Etsa liteko life tse hlokahalang tse kang litekanyetso tsa pono kapa tlhahlobo e bonoang bakeng sa matšoao a lihlahisoa tsa lihlahisoa kapa karohano ea mohato.
Haeba ho hlokahala, fetisa tharollo ka sing ho tlosa likhahla tse setseng kapa likaroloana tse sa sebetsoang.
Mohato oa 8: Ho boloka le ho paka
Fetisetsa tharollo ea lifofane tse lokiselitsoeng tsa HPMC ka lisebelisoa tse loketseng tsa polokelo, ka ho khetheha litlolo tsa litlolo tsa khalase tsa amber kapa lijana tsa polasetiki tse phahameng.
Ngola lijana ka tlhaiso-leseling e hlokahalang joalo ka palo ea batch, letsatsi la tokiso, ho tsepama le maemo a ho boloka le a polokelo.
Boloka tharollo sebakeng se pholileng, se omileng se sirelelitsoeng lebone le mongobo ho boloka botsitso le ba sehatsetsi.
4. Malebela le Mehopolo:
Kamehla latela mekhoa e metle ea laboratori le litataiso tsa polokeho ha li tšoara lik'hemik'hale le lisebelisoa.
Boloka bohloeki le linoko ho pholletsa le ts'ebetso ea ho hlophisa ho qoba tšilafalo.
Lekola phetisetso ea tharollo ea ho lating le substrate e reretsoeng ka li-substrate e reriloeng (matlapa, li-capsules) pele ho kopo e kholo.
Lithuto tsa Bokooa ba ho lekola ts'ebetso ea nako e telele le maemo a polokelo ea tharollo ea ho lema.
Kopa mokhoa oa ho hlophisa le ho boloka litlaleho bakeng sa sepheo sa boleng bo botle le taolo ea taolo.
Post: Mar-07-2024