Hydroxypropylmethylcellulose (HPMC) ke polymer e qhibilihang ka metsing e sebelisoang haholo liindastering tse fapaneng tse kang meriana, lijo, litlolo le kaho. HPMC e tsebahala ka thepa ea eona e ntle ea ho boloka metsi, e etsa hore e be motsoako o loketseng lits'ebetsong tse ngata. Sehloohong sena, re hlahloba lintlha tse amang ho bolokoa ha metsi ha HPMC le mokhoa oa ho ntlafatsa lintlha tsena ho eketsa katleho ea tsona.
1. Boima ba molek'hule
Boima ba limolek'hule tsa HPMC bo phetha karolo ea bohlokoa molemong oa ho boloka metsi. Ha boima ba limolek'hule bo phahame, matla a ho boloka metsi a eketseha. Sena ke hobane boima ba limolek'hule tse phahameng HPMC e na le viscosity e phahameng, e etsang hore e khone ho etsa filimi e teteaneng holim'a substrate, kahoo e fokotsa tahlehelo ea metsi. Ka hona, bakeng sa likopo moo ho boloka metsi ho leng bohlokoa, ho kgothaletswa hore ho be le boima bo phahameng ba molek'hule HPMC.
2. Degree ea ho nka sebaka
The degree of substitution (DS) e bolela palo ea hydroxypropyl le lihlopha tsa methyl ka har'a molek'hule ea HPMC. Ha DS e phahame, matla a ho boloka metsi a matlafala. Sena ke hobane lihlopha tsa hydroxypropyl le methyl li eketsa ho qhibiliha ha HPMC metsing le ho ntlafatsa bokhoni ba eona ba ho theha sebopeho se kang sa gel se ka amohelang limolek'hule tsa metsi. Ka hona, bakeng sa lits'ebetso moo ho boloka metsi e leng ntlha ea bohlokoa, HPMC e nang le boemo bo phahameng ba ho fetola e buelloa.
3. Mocheso le mongobo
Mocheso le mongobo ke lintlha tsa bohlokoa tse amang ho bolokoa ha metsi ho HPMC. Mocheso o phahameng le mongobo o tlase o tla etsa hore metsi a filimi ea HPMC a fetohe mouoane ka potlako, e leng se tla fella ka ho boloka metsi ho fokolang. Ka hona, ho khothalletsoa ho boloka HPMC sebakeng se phodileng le se omileng ho boloka thepa ea eona ea ho boloka metsi.
4. pH boleng
PH ea substrate e boetse e bapala karolo ea bohlokoa ho bolokeng metsi ho HPMC. HPMC e sebetsa haholo maemong a sa nke lehlakore ho isa ho asiti e nyane. Ha pH ea matrix e phahame, ho qhibiliha ha HPMC ho ka fokotseha 'me phello ea ho boloka metsi e tla fokotseha. Ka hona, ho khothaletsoa ho lekola pH ea substrate le ho e lokisa ho ea boemong bo nepahetseng bakeng sa ho boloka metsi hantle.
5. Ho tsepamisa mohopolo
Khatiso ea HPMC e boetse e ama thepa ea eona ea ho boloka metsi. Ka kakaretso, ha khatello ea HPMC e phahame, ho boloka metsi ho betere. Leha ho le joalo, maemong a holimo haholo, viscosity ea HPMC e ka ba holimo haholo, ea etsa hore ho be thata ho e sebelisa le ho hasana ka ho lekana holim'a substrate. Ka hona, ho khothaletsoa ho lekola khatello e nepahetseng ea HPMC bakeng sa ts'ebeliso e 'ngoe le e' ngoe e ikhethileng e le ho fihlela poloko ea metsi e ntle ka ho fetisisa.
Qetellong, HPMC e fetohile thepa ea bohlokoa ka lebaka la thepa ea eona e babatsehang ea ho boloka metsi 'me e bapala karolo ea bohlokoa liindastering tse fapaneng. Lintlha tse amang ho boloka metsi, joalo ka boima ba limolek'hule, tekanyo ea ho fetola, mocheso le mongobo, pH le mahloriso, li ka ntlafatsoa ho eketsa katleho ea eona. Ka ho utloisisa lintlha tsena, re ka etsa bonnete ba hore li-HPMC li fihlella bokhoni ba tsona bo felletseng, e leng ho nolofalletsang ho theha lihlahisoa tse ntlafalitsoeng bakeng sa thepa ea tsona ea ho boloka metsi.
Nako ea poso: Jul-04-2023