Hydroxypropyl methylcellulose, eo hangata e tsejoang ka hore ke HPMC, ke motsoako o sebelisoang haholo oa meriana le tlatsetso ea lijo. Ka lebaka la ho qhibiliha ha eona ho babatsehang, bokhoni ba ho tlama le thepa ea ho etsa lifilimi, e 'nile ea sebelisoa haholo indastering ea meriana. HPMC e boetse e sebelisoa hangata indastering ea lijo e le setenya, emulsifier le stabilizer. Bohloeki ba HPMC bo bohlokoa haholo indastering ea meriana le ea lijo kaha e ama ts'ebetso le polokeho ea sehlahisoa. Sengoliloeng sena se tla tšohla boikemisetso ba bohloeki ba HPMC le mekhoa ea eona.
Li-HPMC ke eng?
Hydroxypropylmethylcellulose (HPMC) ke cellulose ether e nkiloeng ho methylcellulose. Boima ba eona ba molek'hule ke li-Dalton tse 10,000 ho isa ho tse 1,000,000, 'me ke phofo e tšoeu kapa e bosoeu, e sa nkheng le e sa latsoeheng. HPMC e qhibiliha habonolo ka metsing, hape e qhibiliha ka har'a metsoako e meng ea tlhaho e kang ethanol, butanol, le chloroform. E na le litšobotsi tse ikhethang tse kang ho boloka metsi, ho teteaneng le ho tlama bokhoni, e leng se etsang hore e be se loketseng bakeng sa indasteri ea meriana le ea lijo.
Boikemisetso ba bohloeki ba HPMC
Bohloeki ba HPMC bo ipapisitse le lintlha tse 'maloa tse kang degree of substitution (DS), mongobo le molora. DS e emetse palo ea lihlopha tsa hydroxyl tse nkeloang sebaka ke lihlopha tsa hydroxypropyl ka molek'hule ea selulose. Boemo bo phahameng ba ho kenya sebaka bo eketsa ho qhibiliha ha HPMC le ho ntlafatsa bokhoni ba ho etsa lifilimi. Ka lehlakoreng le leng, tekanyo e tlase ea ho nkela sebaka e ka fella ka ho fokotseha ha ho qhibiliha le thepa e fokolang ea ho etsa lifilimi.
HPMC Mokhoa oa Boikemisetso ba Bohloeki
Ho na le mekhoa e 'maloa ea ho fumana bohloeki ba HPMC, ho kenyelletsa le acid-base titration, elemental analysis, high-performance liquid chromatography (HPLC), le infrared spectroscopy (IR). Lintlha tsa mokhoa o mong le o mong ke tsena:
acid-base titration
Mokhoa o ipapisitse le karabelo ea ho se nke lehlakore lipakeng tsa lihlopha tsa acidic le tsa mantlha ho HPMC. Ntlha ea pele, HPMC e qhibiliha ka har'a motsoako 'me ho eketsoa molumo o tsejoang oa acid kapa setsi sa motsoako o tsejoang. Titration e ne e etsoa ho fihlela pH e fihla sebakeng se sa nke lehlakore. Ho tloha ho palo ea asiti kapa setsi se sebelisitsoeng, tekanyo ea ho kenya sebaka e ka baloa.
Tlhahlobo ea mantlha
Tlhahlobo ea mantlha e lekanya peresente ea element ka 'ngoe e teng sampoleng, ho kenyeletsoa khabone, hydrogen le oksijene. Tekanyo ea ho nka sebaka e ka baloa ho tloha ho palo ea ntho ka 'ngoe e teng sampoleng ea HPMC.
High Performance Liquid Chromatography (HPLC)
HPLC ke mokhoa o sebelisoang haholo oa tlhahlobo o arolang likarolo tsa motsoako ho ipapisitsoe le tšebelisano ea bona le mekhahlelo e emeng le e tsamaeang. Ho HPMC, tekanyo ea ho nka sebaka e ka baloa ka ho lekanya karolelano ea hydroxypropyl ho lihlopha tsa methyl ka sampuli.
Infrared Spectroscopy (IR)
Infrared spectroscopy ke mokhoa oa tlhahlobo o lekanyang ho monya kapa ho fetisoa ha mahlaseli a infrared ka sampuli. HPMC e na le litlhōrō tse fapaneng tsa ho monya bakeng sa hydroxyl, methyl le hydroxypropyl, e ka sebelisoang ho fumana tekanyo ea ho kenya sebaka.
Bohloeki ba HPMC bo bohlokoa indastering ea meriana le ea lijo, 'me boikemisetso ba eona bo bohlokoa ho netefatsa polokeho le katleho ea sehlahisoa sa ho qetela. Ho na le mekhoa e mengata ea ho fumana bohloeki ba HPMC, ho kenyelletsa le titration ea acid-base, tlhahlobo ea mantlha, HPLC, le IR. Mokhoa o mong le o mong o na le melemo le mefokolo ea oona mme o ka khethoa ho latela litlhoko tse khethehileng tsa kopo. Ho boloka bohloeki ba HPMC, e tlameha ho bolokoa sebakeng se omeletseng, se phodileng hole le khanya ea letsatsi le litšila tse ling.
Nako ea poso: Aug-25-2023