Hydroxypropyl methylcellulose (HPMC) ke motsoako o sebetsang ka bongata o sebelisoang haholo liindastering tse fapaneng ka lebaka la sebopeho sa eona se ikhethang sa lik'hemik'hale le thepa.
1. Sebopeho sa lik'hemik'hale:
a. Cellulose mokokotlo:
HPMC ke motsoako oa cellulose, ho bolelang hore o tsoa ho cellulose, polysaccharide ea tlhaho e fumanehang maboteng a lisele tsa semela. Cellulose e na le li-unit tse pheta-phetoang tsa β-D-glucose tse hokahantsoeng ke β(1→4) libonto tsa glycosidic.
b. Phapanyetsano:
Ho HPMC, karolo ea hydroxyl (-OH) ea mokokotlo oa cellulose e nkeloa sebaka ke lihlopha tsa methyl le hydroxypropyl. Phapang ena e etsahala ka karabelo ea etherification. Degree of substitution (DS) e bolela palo e tloaelehileng ea lihlopha tsa hydroxyl tse nkeloang sebaka ka yuniti ea tsoekere ka har'a ketane ea cellulose. DS ea lihlopha tsa methyl le hydroxypropyl li fapane, tse amang ts'ebetso ea HPMC.
2. Tšimoloho:
a. Etherification:
HPMC e entsoe ka karabelo ea etherification ea selulose ka propylene oxide le methyl chloride. Ts'ebetso ena e kenyelletsa ho arabela cellulose ka propylene oxide ho hlahisa lihlopha tsa hydroxypropyl ebe ka methyl chloride ho hlahisa lihlopha tsa methyl.
b. Boemo ba taolo e 'ngoe:
DS ea HPMC e ka laoloa ka ho lokisa maemo a karabelo joalo ka mocheso, nako ea karabelo, le khatello ea maikutlo.
3. Tshebetso:
a. Sollubility:
HPMC e qhibiliha ka metsing le lihlapolli tse ling tsa tlhaho, tse kang methanol le ethanol. Leha ho le joalo, ho qhibiliha ha eona ho fokotseha ka ho eketseha ha boima ba limolek'hule le tekanyo ea ho fetola.
b. Moetso oa lifilimi:
HPMC e etsa filimi e bonaletsang, e tenyetsehang ha e qhibiliha ka metsing. Lifilimi tsena li na le matla a matle a mochini le thepa ea thibelo.
C. Viscosity:
Litharollo tsa HPMC li bonts'a boits'oaro ba pseudoplastic, ho bolelang hore viscosity ea bona e fokotseha ka sekhahla sa ho kuta. The viscosity ea HPMC tharollo itšetlehile ka lintlha tse kang mahloriso, boima ba molek'hule, 'me tekanyo ea ho nka sebaka.
d. Ho boloka metsi:
E 'ngoe ea litšobotsi tsa bohlokoa tsa HPMC ke bokhoni ba eona ba ho boloka metsi. Thepa ena e bohlokoa lits'ebetsong tse fapaneng joalo ka thepa ea kaho, moo HPMC e sebelisoang e le sekontiri le se bolokang metsi.
e. Ho khomarela:
HPMC e atisa ho sebelisoa e le sekhomaretsi liindasteri tse sa tšoaneng ka lebaka la bokhoni ba ho theha maqhama matla ho substrates fapaneng.
4. Kopo:
a. Indasteri ea meriana:
Litlhareng tsa meriana, HPMC e sebelisoa e le se tlamellang, se koahelang filimi, se laolang tokollo, le mofetoleli oa viscosity mefuteng ea matlapa.
b. Indasteri ea kaho:
HPMC e eketsoa lireteng tse thehiloeng ho samente, lipolasetere tse thehiloeng ka gypsum le likhomaretsi tsa lithaele ho ntlafatsa bokhoni ba ho sebetsa, ho boloka metsi le ho khomarela.
C. indasteri ea lijo:
Indastering ea lijo, HPMC e sebelisoa e le setenya, se tsitsitseng le se emulsifier lihlahisoa tse kang li-sauces, dressings le ice cream.
d. Lihlahisoa tsa tlhokomelo ea motho ka mong:
HPMC e sebelisoa e le seteifatsi, emulsifier le ho etsa lifilimi lihlahisoa tsa tlhokomelo ea botho tse kang li-shampoo, litlolo le litlolo.
e. Lipente le Liaparo:
Ka lipente le liphahlo, HPMC e sebelisetsoa ho ntlafatsa ho hasana ha mebala, taolo ea viscosity le ho boloka metsi.
Hydroxypropylmethylcellulose (HPMC) ke motsoako o sebetsang ka bongata o nang le mefuta e mengata ea likopo ho pholletsa le liindasteri tse fapaneng. Sebopeho sa eona se ikhethang sa lik'hemik'hale, motsoako le thepa e etsa hore e be motsoako oa bohlokoa ho tsa meriana, thepa ea mohaho, lijo, lihlahisoa tsa tlhokomelo ea botho le lipente / liphahlo. Ho utloisisa thepa ea HPMC ho lumella lits'ebetso tse ikhethileng likarolong tse fapaneng, ho kenya letsoho ts'ebelisong ea eona e pharalletseng le bohlokoa mekhoeng ea sejoale-joale ea tlhahiso.
Nako ea poso: Feb-22-2024