Hydroxypropyl methylcellulose (HPMC) le hypromellose ehlile ke motsoako o le mong, 'me mantsoe ana a sebelisoa hangata ka ho fapanyetsana.Tsena ke mabitso a rarahaneng bakeng sa mefuta e tloaelehileng ea li-polymers tse thehiloeng ho cellulose tse nang le mefuta e mengata ea ts'ebeliso liindastering tse fapaneng tse kenyelletsang meriana, lijo le litlolo.
1. Sebopeho sa lik'hemik'hale le sebopeho:
Hydroxypropylmethylcellulose (HPMC) ke phetoho ea maiketsetso ea selulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela.Sebopeho sa lik'hemik'hale sa HPMC se fumanoa ka ho hlahisa lihlopha tsa hydroxypropyl le methyl motheong oa selulose.Sehlopha sa hydroxypropyl se etsa hore selulose e qhibilihe haholoanyane metsing, 'me sehlopha sa methyl se ntlafatsa botsitso ba sona le ho fokotsa ts'ebetso ea sona.
2. Mokhoa oa tlhahiso:
Tlhahiso ea hydroxypropyl methylcellulose e kenyelletsa ho phekola selulose ka propylene oxide ho hlahisa lihlopha tsa hydroxypropyl ebe ka methyl chloride ho eketsa lihlopha tsa methyl.Tekanyo ea substitution (DS) ea hydroxypropyl le methyl e ka fetoloa nakong ea ts'ebetso ea tlhahiso, e hlahisang limaraka tse fapaneng tsa HPMC tse nang le thepa e fapaneng.
3. Lintho tsa 'mele:
HPMC ke phofo e tsoeu ho isa ho e mosoeu hanyane, ha e na monko ebile ha e latsoehe.Lintho tsa eona tsa 'mele, tse kang viscosity le solubility, li itšetlehile ka tekanyo ea ho fetola le boima ba limolek'hule tsa polymer.Tlas'a maemo a tloaelehileng, e qhibiliha habonolo metsing, e etsa tharollo e hlakileng le e se nang mebala.
4. Merero ea bongaka:
E 'ngoe ea likopo tsa mantlha tsa HPMC ke indastering ea meriana.E sebelisoa haholo joalo ka mothusi oa meriana 'me e bapala likarolo tse fapaneng litokisetsong tsa meriana.HPMC hangata e fumanoa mefuteng ea litekanyetso tse tiileng tsa molomo joalo ka matlapa, li-capsules le lipilisi.E sebetsa e le setlamo se kopanyang, se senyang, le se laoloang ho lokolloa, se tlatsetsang botsitso bo akaretsang le bioavailability ea lithethefatsi.
5. Seabo litokisetsong tse laoloang tsa tokollo:
Bokhoni ba HPMC ba ho etsa li-gel ka litharollo tsa metsi bo etsa hore e be ea bohlokoa mefuteng e laoloang ea lithethefatsi.Ka ho fapanyetsana li-viscosity le thepa ea ho etsa li-gel, bo-rasaense ba meriana ba ka laola sekhahla sa ho lokolloa ha metsoako e sebetsang, kahoo ba finyella ketso e tsitsitseng le e telele ea lithethefatsi.
6. Kopo indastering ea lijo:
Ka indasteri ea lijo, HPMC e sebelisoa e le setenya, se tsitsitseng le emulsifier.E ntlafatsa sebopeho sa lijo tse fapaneng, ho kenyelletsa le li-sauces, sopho le lihlahisoa tsa lebese.Ho feta moo, HPMC e sebelisoa ho baka ho se nang gluten ho ntlafatsa sebopeho le thepa e mongobo ea lihlahisoa tse se nang gluten.
7. Lisebelisuoa tsa kaho le tsa mohaho:
HPMC e sebelisoa indastering ea kaho lihlahisoa tse kang likhomaretsi tsa lithaele, lipolasetere tse thehiloeng ho samente le thepa e thehiloeng ho gypsum.E ntlafatsa ts'ebetso, ho boloka metsi le thepa ea sekhomaretsi ea lihlahisoa tsena.
8. Litlolo le lihlahisoa tsa tlhokomelo ea motho ka mong:
Hypromellose hape ke motsoako o tloaelehileng oa litlolo le lihlahisoa tsa tlhokomelo ea motho.E sebelisoa ho litlolo, litlolo le li-shampoo ka lebaka la thepa ea eona e teteaneng le e tsitsitseng.Ho feta moo, e thusa ho ntlafatsa sebopeho sa kakaretso le maikutlo a sehlahisoa.
9. Ho roala filimi ka har'a meriana:
HPMC e sebelisoa haholo indastering ea meriana bakeng sa ho roala filimi ea matlapa.Matlapa a koahetsoeng ka filimi a fana ka ponahalo e ntlafetseng, masking a tatso le tšireletso khahlanong le maemo a tikoloho.Lifilimi tsa HPMC li fana ka seaparo se boreleli le se ts'oanang, se ntlafatsa boleng ba kakaretso ea sehlahisoa sa lithethefatsi.
13. Qetello:
Hydroxypropyl methylcellulose (HPMC) le hypromellose li bua ka polymer e tšoanang ea cellulose e nang le mefuta e fapaneng ea ts'ebeliso ea meriana, lijo, litlolo le kaho.Lintho tsa eona tse ikhethang, tse kang ho solubility, botsitso le biodegradability, li kenya letsoho ts'ebelisong ea eona e pharaletseng.Ho feto-fetoha ha maemo ha HPMC liindasteri tse fapaneng ho totobatsa bohlokoa ba eona e le thepa e sebetsang ka bongata, 'me e tsoela pele ho ntlafatsa.ho batla le nts'etsopele li ka utulla lits'ebetso tse ling nakong e tlang.
Tlhaloso ena e felletseng e ikemiselitse ho fana ka kutloisiso e felletseng ea hydroxypropyl methylcellulose le hypromellose, ho hlakisa bohlokoa ba tsona mafapheng a fapaneng, le ho hlakisa karolo ea bona ho bopeng lihlahisoa tse ngata le litlhahlobo.
Nako ea poso: Dec-21-2023