Hydroxypropyl methylcellulose (HPMC), e tsejoang hape e le hypromellose, ke polymer e sebetsang ka bongata e sebelisoang haholo indastering ea meriana. Ke semi-synthetic, inert, viscoelastic polymer e nkiloeng ho cellulose, polysaccharide ea tlhaho. HPMC e nkoa e le ea bohlokoa ka lebaka la ho qhibiliha ha eona metsing, tlhaho e seng chefo, le bokhoni ba eona ba ho etsa lifilimi le li-gel.
1. Binder ka Letlapa Formulations
E 'ngoe ea ts'ebeliso ea mantlha ea HPMC litlameng ke e tlamang liforomong tsa matlapa. HPMC e hiriloe ho etsa bonnete ba hore metsoako e ka har'a letlapa e khomarelana 'me e lula e tsitsitse ho fihlela e kenngoa. Matla a eona a tlamang a ntlafatsa matla a matla a matlapa, a etsa hore a se ke a qhekelloa kapa a robeha nakong ea ho paka, ho tsamaisa le ho sebetsana le ona. Ho feta moo, tlhaho e seng ea ionic ea HPMC e tiisa hore ha e sebetsane le lisebelisoa tse ling, ho boloka botsitso le katleho ea metsoako e sebetsang ea meriana (APIs).
2. Laoloang Release Matrix
HPMC e bohlokoa ho nts'etsopele ea tokollo e laoloang (CR) le tokollo e tsitsitseng (SR). Metsoako ena e etselitsoe ho lokolla moriana ka lebelo le reriloeng esale pele, ho boloka maemo a tsitsitseng a lithethefatsi maling ka nako e telele. Bokhoni ba HPMC ba ho etsa li-gel ha bo kopana le maro a ka mpeng bo etsa hore e lokele morero ona. E etsa lera la li-viscous gel ho potoloha letlapa, ho laola ho ata ha moriana. Tšobotsi ena e na le molemo ka ho khetheha bakeng sa lithethefatsi tse nang le index ea phekolo e moqotetsane, kaha e thusa ho boloka mahloriso a plasma a lakatsehang, ka tsela eo e matlafatsa ts'ebetso le ho fokotsa litla-morao.
3. Ho roala filimi
Tšebeliso e 'ngoe ea bohlokoa ea HPMC ke ho koahela filimi ea matlapa le li-capsules. Liaparo tse thehiloeng ho HPMC li sireletsa letlapa ho tloha linthong tsa tikoloho tse kang mongobo, leseli le moea, tse ka senyang metsoako e sebetsang. Ho roala filimi ho boetse ho ntlafatsa boipiletso bo botle ba letlapa, ho ntlafatsa masking ea tatso, 'me ho ka sebelisoa ho fana ka tšireletso ea enteric, ho etsa bonnete ba hore lithethefatsi li lokolloa libakeng tse itseng tsa pampitšana ea gastrointestinal. Ho feta moo, liphahlo tsa HPMC li ka etsoa ho fetola boemo ba ho lokolloa ha moriana, ho thusa lits'ebetsong tse lebisitsoeng tsa phano.
4. Thickening Agent
HPMC e sebetsa e le setsi se matla sa ho tenya mekhoeng ea mokelikeli e kang syrups le suspensions. Bokhoni ba eona ba ho eketsa viscosity ntle le ho fetola haholo thepa e 'ngoe ea sebopeho ho na le molemo ho etsa bonnete ba kabo e tšoanang ea moriana ka har'a mokelikeli, ho thibela sedimentation ea likaroloana tse emisitsoeng, le ho fana ka molomo o lakatsehang. Thepa ena e bohlokoa ka ho khetheha mekhoeng ea bana le ea geriatric, moo boiketlo ba tsamaiso bo leng bohlokoa.
5. Stabilizer in Topical Formulations
Meetsong ea lihlooho tse kang litlolo, li-gel, le litlolo, HPMC e sebetsa joalo ka stabilizer le emulsifier. E thusa ho boloka botsitso le botsitso ba sebopeho, ho etsa bonnete ba hore metsoako e sebetsang e ajoa ka tsela e lekanang. HPMC e boetse e fana ka sebopeho se boreleli, se matlafatsa ts'ebeliso le ho monya ha sehlahisoa letlalong. Sebopeho sa eona se se nang ho teneha se etsa hore se loketse ho sebelisoa ha ho etsoa lihlahisoa bakeng sa letlalo le nang le kutlo.
6. Litokisetso tsa Ophthalmic
HPMC e sebelisoa haholo litokisong tsa mahlo, joalo ka meokho ea maiketsetso le tharollo ea lense ea mahlo. Lintho tsa eona tsa viscoelastic li etsisa filimi ea tlhaho ea ho lla, ho fana ka lubrication le mongobo mahlong. Marotholi a mahlo a thehiloeng ho HPMC a molemo haholo ho batho ba nang le lefu la mahlo a omileng, a fanang ka phomolo ho tsoa ho teneha le ho se phutholohe. Ho feta moo, HPMC e sebelisoa litsamaisong tsa phepelo ea lithethefatsi ea mahlo, moo e thusang ho lelefatsa nako ea ho kopana le moriana ka bokaholimo ba mahlo, ho ntlafatsa katleho ea kalafo.
7. Sebopeho sa Capsule
HPMC e boetse e sebelisoa ha ho etsoa li-capsules tse thata le tse bonolo. E sebetsa e le mokhoa o mong oa gelatin, o fana ka khetho ea meroho bakeng sa likhetla tsa capsule. Li-capsules tsa HPMC li ratoa bakeng sa mongobo oa tsona o tlase, o leng molemo bakeng sa lithethefatsi tse thibelang mongobo. Li boetse li fana ka botsitso bo betere maemong a fapaneng a tikoloho mme ha ho na monyetla oa ho tšela, taba e tloaelehileng ka li-capsules tsa gelatin tse ka amang litlaleho tsa ho lokolloa ha lithethefatsi.
8. Ntlafatso ea Bioavailability
Meetsong e meng, HPMC e ka ntlafatsa bioavailability ea litlhare tse sa qhibiliheng hantle. Ka ho theha matrix ea gel, HPMC e ka eketsa sekhahla sa ho qhibiliha ha moriana ka har'a pampitšana ea mala, ho thusa ho monya hantle. Sena ke sa bohlokoa haholo bakeng sa lithethefatsi tse nang le metsi a fokolang a qhibilihang, kaha ho qhibiliha ho ntlafetseng ho ka ama haholo matla a phekolo ea meriana.
9. Likopo tsa Mucoadhesive
HPMC e bonts'a thepa ea li-mucoadhesive, e etsa hore e tšoanelehe bakeng sa litsamaiso tsa phepelo ea lithethefatsi tsa buccal le sublingual. Litsamaiso tsena li hloka hore moriana o khomarele lera la mucous, ho fana ka tokollo e telele le ho monya ka kotloloho maling, ho feta metabolism ea pele. Mokhoa ona o molemo bakeng sa lithethefatsi tse senyang tikolohong ea asiti ea mpa kapa tse nang le bioavailability e mpe ea molomo.
Ho feto-fetoha ha hydroxypropyl methylcellulose (HPMC) mefuteng ea meriana e ke ke ea feteletsoa. Ts'ebeliso ea eona e qala ho tlama letlapa le ho koaheloa ka filimi ho isa ho tse teteaneng le tse matlafatsang mefuteng e fapaneng. Bokhoni ba HPMC ba ho fetola liprofaele tsa tokollo ea lithethefatsi, ho ntlafatsa bioavailability, le ho fana ka mucoadhesion e boetse e totobatsa bohlokoa ba eona ntlafatsong ea litsamaiso tse tsoetseng pele tsa phano ea lithethefatsi. Ha indasteri ea meriana e ntse e tsoela pele ho fetoha, karolo ea HPMC e ka 'na ea eketseha, e tsamaisoa ke lipatlisiso tse tsoelang pele le boiteko ba nts'etsopele bo reretsoeng ho ntlafatsa phepelo ea lithethefatsi le liphello tsa mokuli.
Nako ea poso: Jun-05-2024