Hydroxypropyl methylcellulose (HPMC) ke thepa ea bohlokoa e nang le mefuta e mengata ea lisebelisoa indastering ea meriana hammoho le liindasteri tse ling tse kang lijo, litlolo le kaho. Tlhokahalo ea HPMC e ntse e hola butle ho theosa le lilemo ka lebaka la thepa ea eona e ikhethang joalo ka ho tiea, ho tlama, ho etsa lifilimi le ho boloka metsi. Sehloohong sena, re tla tšohla mokhoa oa tlhahiso ea alkaline leaching ea hydroxypropyl methylcellulose (HPMC).
Mokhoa oa tlhahiso ea alkali leaching ea hydroxypropyl methylcellulose (HPMC) ke ts'ebetso eo cellulose e sebetsanang le propylene oxide le methyl chloride boteng ba alkali. Ts'ebetso e etsahala tlas'a mocheso, khatello le maemo a laoloang ke nako ho hlahisa lihlahisoa tse phahameng tsa HPMC.
Mohato oa pele oa ho hlahisa HPMC o sebelisa mokhoa oa tlhahiso ea alkaline leaching ke ho lokisa thepa e tala ea cellulose. Cellulose e hloekisoa pele ka ho tlosa litšila leha e le life ebe e fetoloa alkali cellulose ka ho phekoloa ka alkali e kang sodium hydroxide. Mohato ona o bohlokoa hobane o eketsa ts'ebetso ea cellulose ka li-reagents tse sebelisoang mehatong e latelang.
Alkali cellulose e phekoloa ka motsoako oa propylene oxide le methyl chloride tlas'a mocheso o laoloang le khatello. Karabelo pakeng tsa alkali cellulose le reagent e fella ka ho thehoa ha sehlahisoa, e leng motsoako oa hydroxypropyl methylcellulose le lihlahisoa tse ling.
Motsoako ona oa hlatsuoa, oa hloekisoa, 'me oa tlhotloa ho tlosa litšila tse kang li-reagents tse sa sebetsanoang le lihlahisoa. Tharollo e hlahisoang ebe e tsepamisitsoe ke mouoane ho fumana sehlahisoa se phahameng sa HPMC.
Mokhoa oa tlhahiso ea alkali leaching oa hydroxypropyl methylcellulose (HPMC) o na le melemo e mengata ha e bapisoa le mekhoa e meng ea tlhahiso e kang etherification. E 'ngoe ea melemo ke hore ke ts'ebetso e ntle ea tikoloho. Ho fapana le mekhoa e meng, mokhoa oa tlhahiso ea alkali leaching ha o sebelise li-solvents tse kotsi ho tikoloho le bophelo ba batho.
Molemo o mong oa mokhoa ona ke tlhahiso ea lihlahisoa tse phahameng tsa HPMC. Maemo a karabelo a laoloang a netefatsa hore sehlahisoa sa ho qetela ke sa boleng bo ts'oanang 'me se loketse lits'ebetso tse fapaneng.
Tšebeliso ea HPMC indastering ea meriana e bohlokoa bakeng sa tlhahiso ea matlapa, li-capsules le mefuta e meng ea litekanyetso. HPMC e ka sebelisoa e le binder, disintegrant, coating agent, joalo-joalo Tšebeliso ea HPMC lits'ebetsong tsena e tiisa hore foromo ea litekanyetso ke ea boleng bo phahameng le ho finyella litekanyetso tse hlokahalang.
HPMC e boetse e sebelisoa e le motenya, emulsifier le stabilizer indastering ea lijo. Tšebeliso ea HPMC lihlahisoa tsa lijo e netefatsa sebopeho se tsitsitseng, viscosity le boleng.
Indastering ea kaho, HPMC e sebelisoa e le tlatsetso ea samente ho ntlafatsa ts'ebetso, ho boloka metsi le thepa e tlamang ea samente. Tšebeliso ea HPMC e netefatsa hore lihlahisoa tsa kaho ke tsa boleng bo phahameng le ho finyella litekanyetso tse hlokahalang.
Ka kakaretso, mokhoa oa tlhahiso ea alkali leaching oa hydroxypropyl methylcellulose (HPMC) ke mokhoa oa ho hlahisa lihlahisoa tsa boleng bo phahameng ba HPMC 'me o sebelisoa haholo liindastering tse sa tšoaneng tse kang meriana, lijo le kaho. Tšebeliso ea HPMC lits'ebetsong tsena e netefatsa hore sehlahisoa ke sa boleng bo holimo ebile se kopana le maemo a hlokahalang. Mokhoa ona oa tlhahiso o boetse o na le tikoloho ebile o hlahisa sehlahisoa sa HPMC se hloekileng haholo.
Nako ea poso: Sep-15-2023